BDgene

SNP Report

Basic Info
Name rs4532 dbSNP Ensembl
Location chr5:175443147 - 175443147(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele C
Minor Allele Frequence 0.244609
Functional Annotation 5_prime_UTR_variant.
Consequence to Transcript 5_prime_UTR_variant(ENST00000393752)
No. of Studies 2 (Positive: 2; Negative: 0; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Zhang, J., 2013 A/G P-value<0.001, OR=2.10, 95%CI=1.48-2.99 for GG genotype comp...... P-value<0.001, OR=2.10, 95%CI=1.48-2.99 for GG genotype compared with AA genotype. More... Our results showed that the GG genotype of rs4532 locus was...... Our results showed that the GG genotype of rs4532 locus was significantly associated with bipolar disorder compared with AA genotype. More... Positive
Yao, J., 2013 G/A P-value=0.138, I2=40.0%; OR (95% CI)=0.98 (0.69-1...... P-value=0.138, I2=40.0%; OR (95% CI)=0.98 (0.69-1.39) for AG vs AA; OR (95% CI)=2.10(1.48-2.99) for GG vs AA More... Our results showed that the GG genotype of rs4532 locus was ...... Our results showed that the GG genotype of rs4532 locus was significantly associated with bipolar disorder compared with AA genotype. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DRD1 dopamine receptor D1 5q34-q35 11(6/5/0)

SNPs in LD with rs4532 (count: 10) View in gBrowse (chr5:175436902..175464618 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 10)


Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Zhang, J., 2013 no P-value provided With respect to schizophrenia, no significant association was found by a random effects model. Negative
Yao, J., 2013 no P-value With respect to schizophrenia, no significant association was found by a random effects model. Negative

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016