SNP Report

Basic Info

Name	rs138855 dbSNP Ensembl
Location	chr22:49804834 - 49804834(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.342851
Functional Annotation	intron_variant; NMD_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000216267, ENST00000404034, ENST00000404760, ENST00000438393, ENST00000457780); NMD_transcript_variant(ENST00000438393); upstream_gene_variant(ENST00000624882)
No. of Studies	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Severinsen, J. E., 2006 (b)	G/C		P-value = 0.4377 in BD, P-value = 0.4186 in BD and SZ P-value = 0.4377 in BD, P-value = 0.4186 in BD and SZ		Negative
Nyegaard, M., 2010	G/C			None of the 11 Sequenom SNPs showed association with BPD. None of the 11 Sequenom SNPs showed association with BPD.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
BRD1	bromodomain containing 1	22q13.33	2(2/0/0)

SNPs in LD with rs138855 (count: 0) View in gBrowse (chr22:49804834..49804834 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Nyegaard, M., 2010	P-value = 0.93, OR=1.01 in UK/DK sample	Nominal significant association with SZ	Positive
Severinsen, J. E., 2006 (b)	P-value = 0.501 in SZ, P-value = 0.4186 in BD and SZ		Negative

Overlap with MDD from cross-disorder studies (count: 0)