SNP Report

Basic Info

Name	rs715505 dbSNP Ensembl
Location	chr22:39355246 - 39355246(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.335663
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000216155, ENST00000318801, ENST00000328933, ENST00000406293, ENST00000415332, ENST00000489206); NMD_transcript_variant(ENST00000415332); non_coding_transcript_variant(ENST00000489206)
No. of Studies	3 (Positive: 1; Negative: 2; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Verma, R.,2005(a)	G/C	Fisher's exact test: allele P-value = 0.007, chi-square test...... Fisher's exact test: allele P-value = 0.007, chi-square test: genotype P-value = 0.029 in BPAD More...	Significant association was observed in allelic association. Significant association was observed in allelic association.	Positive
Wang, Y.,2009	C/G	allelic association: OR (95%CI)=0.939(0.76-1.16), P-value = ...... allelic association: OR (95%CI)=0.939(0.76-1.16), P-value = 0.555; genotypic association: P-value = 0.745 More...	No significant association was observed No significant association was observed	Negative
Yosifova, A.,2009	G/C	Allelic association: 1st screening: P-value = 0.33, 2nd scre...... Allelic association: 1st screening: P-value = 0.33, 2nd screening: P-value = 0.69, total: P-value = 0.89 More...	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SYNGR1	synaptogyrin 1	22q13	3(2/1/0)

SNPs in LD with rs715505 (count: 9) View in gBrowse (chr22:39311840..39362248 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs12627970		0.851[CEU]
rs715503	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]
rs2076125	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.851[CEU]
rs12627761		0.851[CEU]
rs5757609	downstream_gene_variant	0.855[CEU]
rs2069235	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.938[CHB]; 0.888[JPT]
rs5757611	downstream_gene_variant	0.851[CEU]
rs2049986	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.819[CHB]
rs5757610	downstream_gene_variant	0.861[CEU]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Verma, R.,2005(a)	Fisher's exact test:allele P-value = 0.00007, chi-square test:genotype P-value = 0.0004 in SCZ	Significant association was observed in allelic association.	Positive

Overlap with MDD from cross-disorder studies (count: 0)