BDgene

SNP Report

Basic Info
Name rs11098403 dbSNP Ensembl
Location chr4:117725752 - 117725752(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.216853
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Zhang, C., 2016 G/A P-value=0.03, OR=0.80, 95%CI=0.65-0.98 P-value=0.03, OR=0.80, 95%CI=0.65-0.98 In a comparison between the BD and control groups, no signif...... In a comparison between the BD and control groups, no significant difference was observed in individual SNP marker genotypes or allele distributions. More... Negative
Lencz, T., 2013 Replication P-value=5.40E-05 for bipolar disorder when consi...... Replication P-value=5.40E-05 for bipolar disorder when considering the non-discovery cohorts alone; Overall replication, P-value=1.46E-07; OR=1.09; 95% CI: 1.04-1.14; meta P-value=9.49E-12 (OR=1.13; 95% CI: 1.08-1.17) when all cohorts were included. meta P-value=9.49E-12 (OR=1.13; 95% CI: 1.08-1.17) when all cohorts were included. More... The top single-nucleotide polymorphism (SNP; rs11098403) dem...... The top single-nucleotide polymorphism (SNP; rs11098403) demonstrates consistent effects across 11 replication and extension cohorts, resulting in Pmeta=9.49 x 10(-12) (odds ratio (OR)=1.13, 95% confidence interval (CI): 1.08-1.17) across disorders. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 4q26 1(1/0/0)

SNPs in LD with rs11098403 (count: 50) View in gBrowse (chr4:117627788..117805096 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 50)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Lencz, T., 2013 meta, P-value=2.67E-08 (OR=1.15, 95% confidence interval (CI): 1.08-1.21) when considering the schizophrenia cohorts alone; meta P-value=9.49E-12 (OR=1.13; 95% CI: 1.08-1.17) when all cohorts were included. Replication P-value=9.74E-04 for SZ when considering the non-discovery cohorts alone; Overall replication, P-value=1.46E-07; OR=1.09; 95% CI: 1.04-1.14 The top single-nucleotide polymorphism (SNP; rs11098403) demonstrates consistent effects across 11 replication and extension cohorts, totalling 23, 191 samples across multiple ethnicities, resulting in Pmeta=2.67 x 10(-8) (OR=1.15, 95% CI: 1.08-1.21) for schizophrenia alone. Positive

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016