BDgene

SNP Report

Basic Info
Name rs2295814 dbSNP Ensembl
Location chr10:62811516 - 62811516(1)
Variant Alleles G/A
Ancestral Allele G
Minor Allele A
Minor Allele Frequence 0.0750799
Functional Annotation downstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000242480, ENST00000373783, ENST00000411732, ENST00000439032, ENST00000493899, ENST00000637191, LRG_239t1)
No. of Studies 3 (Positive: 1; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Balan S, 2013 A/G Pearson's χ2 test, genotypic P-value=0.62, Fisher's exact t...... Pearson's χ2 test, genotypic P-value=0.62, Fisher's exact test, allelic P-value=0.95, OR=0.99, 95% CI=0.81-1.22; meta-analysis, overall effect: Z=0.79, P-value=0.43 for fixed model, Z=0.86, P-value=0.39 for random model More... There were no significant difference in genotype and allele ...... There were no significant difference in genotype and allele frequencies of EGR2 SNPs between bipolar disorder patients and controls. Themeta-analysis of the two studies also showed no significant association in both random-effects and fixed-effects model, and a high heterogeneity among the studies was observed with I2 values ranging from 47% to 78%. More... Negative
Gallitano, A. L.,2012 Association analysis: FBAT, P-value > 0.05 Association analysis: FBAT, P-value > 0.05 No significant association was observed in BD. No significant association was observed in BD. Negative
Kim, S. H.,2011 G/A For BD, chi-square tests: allele, OR=1.748, X2=8....... For BD, chi-square tests: allele, OR=1.748, X2=8.9817, P-value = 0.0027, P-value(permutation)=0.0164; Fisher's exact test, genotype, X2=11.8998, P-value = 0.0026 More... Significant associations were found in both allele and genot...... Significant associations were found in both allele and genotype association. More... Positive

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
EGR2 early growth response 2 10q21.1 3(1/2/0)
ADO 2-aminoethanethiol (cysteamine) dioxygenase 10q21.3 Mapped by Literature SNP

SNPs in LD with rs2295814 (count: 15) View in gBrowse (chr10:62789094..62873148 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 15)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Kim, S. H.,2011 For SZ, chi-square tests:allele, OR=1.451, X2=3.1172, P-value = 0.0775, P-value(permutation)=0.3337;Fisher's exact test, genotype, X2=3.2943, P-value = 0.1926 No significant association was observed. Negative

Overlap with MDD from cross-disorder studies (count: 0)