BDgene

SNP Report

Basic Info
Name rs2073831 dbSNP Ensembl
Location chr13:76924565 - 76924565(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.307508
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000426582)
No. of Studies 2 (Positive: 0; Negative: 1; Trend: 1)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Lee, M. T.,2011 C/T Genome-wide association: in joint analysis, C vs. T, P-value...... Genome-wide association: in joint analysis, C vs. T, P-value = 9.74E-06; genotype, P-value = 1.35E-05 More... Suggestive association was found. Suggestive association was found. Trend
Lim C.H., 2014 C/T T All ethnicities: OR=0.99, 95%CI =0.80-1.23, P-value=0.94; Ma...... All ethnicities: OR=0.99, 95%CI =0.80-1.23, P-value=0.94; Malay: OR=0.90, 95%CI =0.40-1.35, P-value=0.602; Chinese: OR=0.92, 95%CI =0.07-1.26, P-value=0.612; Indian: OR=1.16, 95%CI =0.74-1.80, P-value=0.524 More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
KCTD12 potassium channel tetramerization domain containing 12 13q21 2(0/1/1)
BTF3P11 basic transcription factor 3 pseudogene 11 13q22 Mapped by Literature SNP

SNPs in LD with rs2073831 (count: 0) View in gBrowse (chr13:76924565..76924565 )

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Lim C.H., 2014 All ethnicities: OR=1.07, 95%CI =0.90-1.28, P-value=0.445; Malay: OR=0.68, 95%CI =0.49-0.95, P-value=0.025; Chinese: OR=1.35, 95%CI =1.04-1.74, P-value=0.024; Indian: OR=1.18, 95%CI =0.81-1.70, P-value=0.387 KCTD12 rs2073831 was significantly associated with SZ in Malays and Chinese (P= 0.024 and 0.025, respectively). Positive

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016