Gene Report

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Basic Info

Approved Symbol	NLRC5
Symbol Alias	NOD27, CLR16.1, FLJ21709
Approved Name	NLR family, CARD domain containing 5
Name Alias	nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5, "NOD-like receptor C5"
Location	16q13
Position	chr16:56989485-57083531, 1
External Links	HGNC: 29933 Entrez Gene: 84166 Ensembl: ENSG00000140853 UCSC: uc021tiu.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs821470	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[20639463]	283
GO:0045087	innate immune response	biological process	IMP[20434986]; TAS	49

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[20061403]	322
GO:0005515	protein binding	molecular function	IPI[20434986]	563
GO:0045345	positive regulation of MHC class I biosynthetic process	biological process	IDA[20639463]	1
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	molecular function	IDA[20639463]	9
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IDA[20434986]	6
GO:0043549	regulation of kinase activity	biological process	IDA[20434986]	1
GO:0051607	defense response to virus	biological process	IEP[20061403]	6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[20639463]	91
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	biological process	IDA[20061403]; IMP[20639463]	1
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	biological process	IDA[20434986]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	biological process	IDA[20061403]	1
GO:0032480	negative regulation of type I interferon production	biological process	TAS	1
GO:0005829	cytosol	cellular component	IDA[20639463]; TAS	223

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs821470	chr16:57024670 - 57024670(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs891140		chr16:57021802 - 57021802(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs1167742		chr16:57020174 - 57020174(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16q12.2-23.1	chr16:52600000-79200000	1 (0/0/1)
16q13	chr16:56000000-57300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

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Region: chr16:56989485..57083531 View in gBrowse