BDgene

SNP Report

Basic Info
Name rs710193 dbSNP Ensembl
Location chr22:40827186 - 40827186(1)
Variant Alleles C/T
Ancestral Allele C
Minor Allele T
Minor Allele Frequence 0.0321486
Functional Annotation downstream_gene_variant; intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant.
Polyphen Annotation: benign(ENST00000216218)
SIFT Annotation: tolerated(ENST00000216218)
Consequence to Transcript downstream_gene_variant(ENST00000413424, ENST00000455824); intron_variant(ENST00000620312); missense_variant(ENST00000216218); non_coding_transcript_exon_variant(ENST00000480048); non_coding_transcript_variant(ENST00000480048)
No. of Studies 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) C/T CLUMP T1 P-value = 1, CLUMP T4 P-value = 1 for BPD; CLUMP T...... CLUMP T1 P-value = 1, CLUMP T4 P-value = 1 for BPD; CLUMP T1 P-value = 0.7631, CLUMP T4 P-value = 0.7631 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.3292 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2317 for BPD and SZ in the Case-Control Sample From Scotland More... Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 22q13.2 1(1/0/0)

SNPs in LD with rs710193 (count: 0) View in gBrowse (chr22:40827186..40827186 )

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) CLUMP T1 P-value = 0.7065, CLUMP T4 P-value = 0.7065 for SZ; CLUMP T1 P-value = 0.7631, CLUMP T4 P-value = 0.7631 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.2758 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2317 for BPD and SZ in the Case-Control Sample From Scotland Negative

Overlap with MDD from cross-disorder studies (count: 0)