SNP Report

Basic Info

Name	rs3918346 dbSNP Ensembl
Location	chr12:108888108 - 108888108(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.430711
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000548052); intron_variant(ENST00000228476, ENST00000547122, ENST00000547166, ENST00000547768, ENST00000549215, ENST00000551281); NMD_transcript_variant(ENST00000547122, ENST00000549215)
No. of Studies	3 (Positive: 0; Negative: 3; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result Category
Prata, D., 2008		data not shown data not shown	Analysis of each SNP individually showed no significant asso...... Analysis of each SNP individually showed no significant association. More...	Negative
Papagni, S. A.,2011	C/T	Diagnosisxgenotype interaction: in the left precuneus (p>0.0...... Diagnosisxgenotype interaction: in the left precuneus (p>0.05).In the right posterior cingulate gyrus (p>0.05). More...	There were no diagnostic groupÃ—genotype interactions which ...... There were no diagnostic groupÃ—genotype interactions which involved the group of bipolar patients. More...	Negative
Bass, N. J.,2009	C/T	chi-squared tests: for BP, allele, P-value > 0.05 chi-squared tests: for BP, allele, P-value > 0.05	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DAOA	D-amino acid oxidase activator	13q33.2	21(13/7/1)
DAO	D-amino-acid oxidase	12q24.11	5(1/4/0)

SNPs in LD with rs3918346 (count: 0) View in gBrowse (chr12:108888108..108888108 )

Overlap with SZ from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Bass, N. J.,2009	chi-squared tests:for SCZ, allele, X²(1 d.f.)=0.976, P-value = 0.323	No significant association was observed.	Negative
Papagni, S. A.,2011	Diagnosisxgenotype interaction:in the left precuneus (Z-score=4.79, p=0.004 after FWE correction), which also expressed deactivation during generation relative to baseline across different diagnostic and genotypic groups.Exploration of the parameter estimates revealed that, in this region, deactivation during generation relative to baseline was less pronounced in schizophrenic patients with one or two copies of the T allele than those without it (Z-score=4.55, p=0.012 after FWE correction); in contrast the opposite trend was expressed amongst healthy volunteers (Zscore= 2.77, p<0.01 uncorrected)In the right posterior cingulate gyrus (Z-score=4.42, p=0.021 after FWE). In this region, there was activation during generation in patients with schizophrenia who had at least one copy of the T allele while there was deactivation in those without it (Z-score=5.11, p=0.001 after FWE)	This revealed two regions which expressed a significant diagnosisÃ—genotype interaction at p<0.05 after FEW correction for multiple comparisons.	Positive

Overlap with MDD from cross-disorder studies (count: 0)