SNP Report

Basic Info

Name	rs3131296 dbSNP Ensembl
Location	chrCHR_HSCHR6_MHC_SSTO_CTG1:32212897 - 32212897(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.0784744
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000375023); upstream_gene_variant(ENST00000474612, ENST00000425600, ENST00000466682, ENST00000437843, ENST00000485109, ENST00000454571, ENST00000471956, ENST00000439349, ENST00000465833, ENST00000383264, ENST00000476219, ENST00000457094, ENST00000495284)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Williams, H. J.,2011			Armitage trend test: P-value = 0.01, OR=1.14, 95%CI=(1.02-1....... Armitage trend test: P-value = 0.01, OR=1.14, 95%CI=(1.02-1.25) More...	Significant association was found. Significant association was found.	Positive
Steinberg, S.,2012		G	Association results in bipolar disorder follow-up samples(7,...... Association results in bipolar disorder follow-up samples(7,333 cases; 43,779 controls):OR(95% CI) = 1.02 (0.96, 1.09),P-value = 0.46 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NOTCH4	notch 4	6p21.3	2(0/2/0)

SNPs in LD with rs3131296 (count: 0) View in gBrowse (chrCHR_HSCHR6_MHC_SSTO_CTG1:32212897..32212897 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Steinberg, S.,2012	Association results in schizophrenia follow-up samples(10,671 cases; 23,900 controls):OR(95% CI) = 1.15 (1.08, 1.21),P-value = 1.4 x 10-6	Suggestive association was found.	Trend

Overlap with MDD from cross-disorder studies (count: 0)