Gene Report

Approved Symbol	IMPA2
Approved Name	inositol(myo)-1(or 4)-monophosphatase 2
Location	18p11.2
Position	chr18:11981025-12030883, 1
External Links	HGNC: 6051 Entrez Gene: 3613 Ensembl: ENSG00000141401 UCSC: uc002kqp.2
No. of Studies	4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bloch, P. J., 2010	SNP: rs1787984, rs3786285, rs3974759, rs585247, rs589247, rs613993, rs636173, rs650727, rs669838 Haplotype: rs1787984 - rs585247 - rs3974759(ATT), rs1787984 - rs585247 - rs3974759(GCA), rs1787984 - rs585247 - rs3974759(HTA), rs1787984 - rs585247 - rs3974759(ATA), rs1787984 - rs585247 - rs3974759(GTT), rs650727 - rs589247 - rs669838 - rs636173(CGGG), rs650727 - rs589247 - rs669838 - rs636173(TATA), rs650727 - rs589247 - rs669838 - rs636173(CGTA)	Our study did not show strong support for an association between the tested IMPA2 polymorphisms and susceptibility to BPD.	Negative	Comment on Study
Dimitrova, A.,2005	SNP: rs3786282 Other variant: IMPA2_443G>A (R148Q), IMPA2_-461C>T, IMPA2_599+97G>A, IMPA2_599+99G>A, IMPA2_-97-15G>A	No SNP showed association with BP. We cannot find support for the involvement of variation in IMPA2 in susceptibility to bipolar disorder, but the role of this and other genes from the phosphoinositol signalling pathway in predicting response to lithium treatment merits further investigation.	Negative	Comment on Study
Ohnishi, T., 2007	SNP: rs11545506, rs2075824, rs2075825, rs3786282, rs3786284, rs3786291, rs594235, rs607200, rs613993, rs640088, rs644710, rs971362, rs971363 Haplotype: IMPA2_-708G>A - rs2075824(), IMPA2_-708G>A - rs2075824 - IMPA2_-207T>C(), rs2075824 - IMPA2_-207T>C(), rs971362 - IMPA2_-708G>A(), rs971362 - IMPA2_-708G>A - rs2075824(), rs971362 - IMPA2_-708G>A - rs2075824 - IMPA2_-207T>C - IMPA2_-185A>G(T-A-T-C-G), rs971362 - IMPA2_-708G>A - rs2075824 - IMPA2_-207T>C - IMPA2_-185A>G(T-G-T-C-G), rs971362 - IMPA2_-708G>A - rs2075824 - IMPA2_-207T>C - IMPA2_-185A>G(G-G-C-T-G), rs971362 - IMPA2_-708G>A - rs2075824 - IMPA2_-207T>C - IMPA2_-185A>G(G-G-C-T-A) Other variant: IMPA2_-207T>C, IMPA2_-185A>G, IMPA2_-708G>A, IMPA2_IVS1-15G>A, IMPA2_IVS5+13-14InsA	We observed association of IMPA2 promoter single nucleotide polymorphisms (SNPs) (-461C and -207T) with bipolar disorder; in vitro promoter assay and genetic haplotype analysis showed that the combination of (-461C)-(-207T)-(-185A) drove enhanced transcription and the haplotypes containing (-461C)-(-207T)-(-185A) contributed to risk for bipolar disorder; expression study on post-mortem brains revealed increased transcription from the IMPA2 allele that harbored (-461C)-(-207T)-(-185A) in the frontal cortex of bipolar disorder patients.	Positive	Comment on Study
Sjoholt, G., 2004	Haplotype: IMPA2_159T>C - IMPA2_230+141G>A - IMPA2_382 - 44G>A(T-G-G), IMPA2_-185A>G - IMPA2_-97 - 15G>A - IMPA2_159T>C(A-G-T), IMPA2_-207T>C - IMPA2_-185A>G - IMPA2_-97 - 15G>A(T-A-G), IMPA2_230+141G>A - IMPA2_382 - 44G>A - IMPA2_443G>A (R148Q)(G-G-G), IMPA2_382 - 44G>A - IMPA2_443G>A (R148Q) - IMPA2_490+13_14insA(G-G-0), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(C-0-T), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(0-T-A), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(C-0-T-A ), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(C-0-T-G ), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(T-0-C-G ), IMPA2_-461C>T - IMPA2_-241_-237dup - IMPA2_-207T>C - IMPA2_-185A>G(T-D-C-G ), IMPA2_-97-15G>A - IMPA2_159T>C - IMPA2_230+141G>A(G-T-G) Other variant: IMPA2_159T>C, IMPA2_230+141G>A, IMPA2_382-44G>A, IMPA2_443G>A (R148Q), IMPA2_490+13_14insA, IMPA2_-97-15G>A, IMPA2_-207T>C, IMPA2_-461C>T, IMPA2_-185A>G, IMPA2_-241_-237dup	The association between manic-depressive illness and IMPA2 variants supports several reports on the linkage of bipolar disorder to chromosome 18p11.2, and sustains the possible role of IMPA2 as a susceptibility gene in bipolar disorder.	Positive	Comment on Study

Region: chr18:11981025..12030883 View in gBrowse