SNP Report

Basic Info

Name	rs4820059 dbSNP Ensembl
Location	chr22:31950481 - 31950481(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.22484
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000248975, ENST00000397492, ENST00000420430, ENST00000443669, ENST00000471374, ENST00000479649); NMD_transcript_variant(ENST00000443669); non_coding_transcript_variant(ENST00000471374, ENST00000479649); upstream_gene_variant(ENST00000486651)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Grover, D.,2009			P-value: Genotypic transmission: 0.008 (psychotic BP) and Al...... P-value: Genotypic transmission: 0.008 (psychotic BP) and Allelic transmission: 1.Standard BP: Major allele: 0.47(Additive Model), 0.43(Dominant Model); Minor allele: 0.47(Additive Model), 0.10(Dominant Model) 2.Psychotic BP: Major allele: 0.07(Additive Model), 0.89(Dominant Model); Minor allele: 0.07(Additive Model), 0.008(Dominant Model) 3.Mood-incongruent psychotic BP: Major allele: 0.91(Additive Model), 0.67(Dominant Model); Minor allele: 0.91(Additive Model), 0.61(Dominant Model) More...	It had evidence of association with BP that was impacted by ...... It had evidence of association with BP that was impacted by the psychotic features covariate. More...	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
C22orf24	chromosome 22 open reading frame 24	22q12.1-q12.3	Mapped by Literature SNP
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	22q12.1-q13.1	3(2/0/1)

SNPs in LD with rs4820059 (count: 0) View in gBrowse (chr22:31950481..31950481 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Grover, D.,2009	LRT P-value:0.03(Psychotic features), 0.76(Mood-incongruent psychotic features)	It had evidence of association with BP that was impacted by the psychotic features covariate.	Positive

Overlap with MDD from cross-disorder studies (count: 0)