Gene Report

Basic Info
Approved Symbol PALB2
Symbol Alias FLJ21816, FANCN
Approved Name partner and localizer of BRCA2
Name Alias Fanconi anemia, complementation group N
Location 16p12.1
Position chr16:23603160-23641310, -1
External Links HGNC: 26144
Entrez Gene: 79728
Ensembl: ENSG00000083093
UCSC: uc002dlx.1
No. of Studies 5 (Positive: 2; Negative: 2; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Moskvina, V.,2009 In BP:Smallest P-value per gene=0.0005, Product of P truncation <=0.01=0.0005, Product of P truncation <=0.001=0.0005. It showed evidence for association with BD. Positive Comment on Study
Ollila, H. M.,2009 SNP: rs420259 It showed no evidence for association with BPI in our study. Negative Comment on Study
Yosifova, A.,2009 SNP: rs420259 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Georgi, B., 2014 SNP: rs45551636 Putative damaging exonic variant was found within this gene. Trend Comment on Study
Tesli, M.,2010 SNP: rs420259 Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 11)

GO terms by PBA (count: 1)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 3)

Literature-origin SNPs (count: 2)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr16:23603160..23641310 View in gBrowse
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