Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	GTF3C5
Symbol Alias	TFiiiC2-63, TFIIIC63, TFIIICepsilon
Approved Name	general transcription factor IIIC, polypeptide 5, 63kDa
Previous Name	general transcription factor IIIC, polypeptide 5 (63kD)
Name Alias	transcription factor IIIC, 63 kD
Location	9q34.13
Position	chr9:133030675-133058503, 1
External Links	HGNC: 4668 Entrez Gene: 9328 Ensembl: ENSG00000148308 UCSC: uc004cci.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs3011267	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IC[17409385]	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000127	transcription factor TFIIIC complex	cellular component	IDA[17409385]	1
GO:0042797	tRNA transcription from RNA polymerase III promoter	biological process	IC[17409385]	1
GO:0005515	protein binding	molecular function	IPI[17409385]	563
GO:0006383	transcription from RNA polymerase III promoter	biological process	IC[17409385]; TAS	2
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter	biological process	IC[17409385]	1
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0006351	transcription, DNA-templated	biological process	IC[17409385]	103
GO:0010467	gene expression	biological process	TAS	41
GO:0035914	skeletal muscle cell differentiation	biological process	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
RNApol3Pathway	RNA polymerase III transcription	2

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GTF3C5	GTF3C4	NO	in vitro;in vivo	10523658
GTF3C5	GTF3C3	NO	in vitro;in vivo	10373544
GTF3C5	BRF1	NO	in vitro	10373544

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3011267	chr9:133005806 - 133005806(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q33.3-34.3	chr9:123100000-138394717	1 (0/1/0)
9q34	chr9:127500000-138394717	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr9:133030675..133058503 View in gBrowse