Gene Report

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Basic Info

Approved Symbol	GTF3C5
Symbol Alias	TFiiiC2-63, TFIIIC63, TFIIICepsilon
Approved Name	general transcription factor IIIC, polypeptide 5, 63kDa
Previous Name	general transcription factor IIIC, polypeptide 5 (63kD)
Name Alias	transcription factor IIIC, 63 kD
Location	9q34.13
Position	chr9:133030675-133058503, 1
External Links	HGNC: 4668 Entrez Gene: 9328 Ensembl: ENSG00000148308 UCSC: uc004cci.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs3011267	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IC[17409385]	83

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000127	transcription factor TFIIIC complex	cellular component	IDA[17409385]	1
GO:0042797	tRNA transcription from RNA polymerase III promoter	biological process	IC[17409385]	1
GO:0005515	protein binding	molecular function	IPI[17409385]	563
GO:0006383	transcription from RNA polymerase III promoter	biological process	IC[17409385]; TAS	2
GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter	biological process	IC[17409385]	1
GO:0005654	nucleoplasm	cellular component	TAS	163
GO:0006351	transcription, DNA-templated	biological process	IC[17409385]	103
GO:0010467	gene expression	biological process	TAS	41
GO:0035914	skeletal muscle cell differentiation	biological process	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
RNApol3Pathway	RNA polymerase III transcription	2

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
GTF3C5	GTF3C3	NO	in vitro;in vivo	10373544
GTF3C5	BRF1	NO	in vitro	10373544
GTF3C5	GTF3C4	NO	in vitro;in vivo	10523658

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3011267	chr9:133005806 - 133005806(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q33.3-34.3	chr9:123100000-138394717	1 (0/1/0)
9q34	chr9:127500000-138394717	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

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Region: chr9:133030675..133058503 View in gBrowse