Gene Report

Basic Info
Approved Symbol CRY2
Approved Name cryptochrome circadian clock 2
Previous Name cryptochrome 2 (photolyase-like)
Location 11p11.2
Position chr11:45847118-45883248, 1
External Links HGNC: 2385
Entrez Gene: 1408
Ensembl: ENSG00000121671
UCSC: uc010rgn.2
No. of Studies 5 (Positive: 3; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Byrne, E. M., 2014 SNP: rs4132063 P-value=0.07. The most significant single SNP association with BPD was with rs4132063(P=0.0006), a SNP located upstream of CRY2. Negative Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Mansour, H. A., 2006 No significant association was detected with Pittsburgh BD1 using CC test, but significant association (P<0.05) was detected in BD1 using TDT test. Positive Comment on Study
Sjoholm, L. K.,2010 SNP: rs10838524, rs10838527, rs3824872, rs7123390
Haplotype: rs10838524 - rs7123390 - rs10838527 - rs3824872(A-A-A-C), rs10838524 - rs7123390 - rs10838527 - rs3824872(A-G-A-A), rs10838524 - rs7123390 - rs10838527 - rs3824872(A-G-G-A), rs10838524 - rs7123390 - rs10838527 - rs3824872(G-A-A-C), rs10838524 - rs7123390 - rs10838527 - rs3824872(G-G-A-C)
In conclusion, this is the first report of genetic association between the circadian gene CRY2 and a severe form of human bipolar disorder. Positive Comment on Study
Mansour, H. A.,2009 SNP: rs1554338 Gene-based tests:X<sup>2</sup>=5.443, P-value = 0.119 in recessive model, X<sup>2</sup>=4.967, P-value = 0.133 in additive model, X<sup>2</sup>=1.486, P-value = 0.768 in dominant model in BPI. Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 30)

GO terms by PBA (count: 2)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 19)

Literature-origin SNPs (count: 6)

LD-proxies (count: 13)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr11:45847118..45883248 View in gBrowse
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