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Meta-analysis Report
Comment on Study | View All Comments on Study |
Reference | Detera-Wadleigh, S. D., 2006 PMID: 16581030 | ||
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Citation | Detera-Wadleigh, S. D. and F. J. McMahon (2006). "G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis." Biol Psychiatry 60(2): 106-114. | ||
Disease Type | Bipolar Disorder & Schizophrenia | ||
Study Type | Candidate-gene association study |
Samples | 11 genetic-association studies: One study was excluded because alleles were not identified in the individual marker analyses. Seven studies focused on schizophrenia or psychosis not otherwise specified, two studies focused on bipolar affective disorder, one study focused on both, and one study focused on panic disorder. | ||
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Statistic Method | To accommodate the great variation across studies in the test statistics used and the way in which results were reported, the meta-analysis was performed with the Fisher method, which can combine p values across studies without need of the primary data. | ||
Basic Result | Their meta-analysis of published association studies shows highly significant evidence of association between nucleotide variations in the G72/G30 region and schizophrenia, along with compelling evidence of association with bipolar disorder. But the associated alleles and haplotypes are not identical across studies, and some strongly associated variants are located ~50 kb telomeric of G72. The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs947267 | DAOA DAOA-AS1 | A/C | Fisher P-value = 0.2256 for all, P-value = 0.2513 for BP Only | Negative | ||
rs778294 | DAOA DAOA-AS1 | A/G | Fisher P-value = 0.7598 for all, P-value = 0.8368 for BP Only | Negative | ||
rs954581 | DAOA-AS1 DAOA | C/T | Fisher P-value = 0.5966 for all, P-value = 0.8368 for BP Only | Negative | ||
rs746187 | DAOA | C/T | Fisher P-value = 0.5966 for all | Negative | ||
rs778293 | DAOA | A/G | Fisher P-value = 0.0003 for all | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More... | Positive | |
rs3918341 | DAOA DAOA-AS1 | A/G | Fisher P-value = 0.5966 for all | Negative | ||
rs3918342 | DAOA | C/T | Fisher P-value = 0.0000 for all, P-value = 0.0309 for BP Only | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... | Positive | |
rs3916970 | DAOA-AS1 DAOA | A/G | Fisher P-value = 0.5966 for all | Negative | ||
rs3916971 | DAOA-AS1 DAOA | C/T | Fisher P-value = 0.0919 for all | Negative | ||
rs3916966 | DAOA-AS1 DAOA | A/C | Fisher P-value = 0.0413 for all | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More... | Positive | |
rs3916967 | DAOA DAOA-AS1 | A/G | Fisher P-value = 0.0734 for all | Negative | ||
rs3916964 | DAOA | C/T | Fisher P-value = 0.1138 for all | Negative | ||
rs3916965 | DAOA | A/G | Fisher P-value = 0.0001 for all | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. More... | Positive | |
rs1935062 | DAOA DAOA-AS1 | A/C | Fisher P-value = 0.0143 for all, P-value = 0.0019 for BP Only | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... | Positive | |
rs2391191 | DAOA DAOA-AS1 | A/G | Fisher P-value = 0.0000 for all, P-value = 0.2513 for BP Only | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More... | Positive | |
rs1421292 | DAOA | A/T | Fisher P-value = 0.001 for all | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More... | Positive | |
rs1935058 | DAOA-AS1 DAOA | C/T | Fisher P-value = 0.0015 for all, P-value = 0.0153 for BP Only | When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More... | Positive | |
rs1341402 | DAOA DAOA-AS1 | C/T | Fisher P-value = 0.0505 for all, P-value = 0.0832 for BP Only | Negative |
Gene | Statistical Values/Author Comments | Result Category |
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DAOA | In summary, this meta-analysis supports significant association of markers in the G72 region with bo...... In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder. More... | Positive |
Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
---|---|---|---|---|---|
SZ | rs954581 | DAOA-AS1 DAOA | Fisher P-value = 0.5966 for all, P-value = 1 for SCZ Only | Negative | |
SZ | rs947267 | DAOA DAOA-AS1 | Fisher P-value = 0.2256 for all, P-value = 0.9478 for SCZ Only | Negative | |
SZ | rs778294 | DAOA DAOA-AS1 | Fisher P-value = 0.7598 for all, P-value = 0.9373 for SCZ Only | Negative | |
SZ | rs778293 | DAOA | Fisher P-value = 0.0003 for all, P-value = 0.0033 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. | Positive |
SZ | rs3916965 | DAOA | Fisher P-value = 0.0001 for all, P-value = 0.0002 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. | Positive |
SZ | rs3916966 | DAOA-AS1 DAOA | Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. | Positive |
SZ | rs3916967 | DAOA DAOA-AS1 | Fisher P-value = 0.0734 for all, P-value = 0.0734 for SCZ Only | Negative | |
SZ | rs3916970 | DAOA-AS1 DAOA | Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only | Negative | |
SZ | rs3916971 | DAOA-AS1 DAOA | Fisher P-value = 0.0919 for all, P-value = 0.0919 for SCZ Only | Negative | |
SZ | rs3918341 | DAOA DAOA-AS1 | Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only | Negative | |
SZ | rs3918342 | DAOA | Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. | Positive |
SZ | rs746187 | DAOA | Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only | Negative | |
SZ | rs1341402 | DAOA DAOA-AS1 | Fisher P-value = 0.0505 for all, P-value = 0.9667 for SCZ Only | Negative | |
SZ | rs1421292 | DAOA | Fisher P-value = 0.001 for all, P-value = 0.0092 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. | Positive |
SZ | rs1935058 | DAOA-AS1 DAOA | Fisher P-value = 0.0015 for all, P-value = 0.4416 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. | Positive |
SZ | rs1935062 | DAOA DAOA-AS1 | Fisher P-value = 0.0143 for all, P-value = 0.9804 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers. | Positive |
SZ | rs2391191 | DAOA DAOA-AS1 | Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only | When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb. | Positive |
SZ | rs3916964 | DAOA | Fisher P-value = 0.1138 for all, P-value = 0.1138 for SCZ Only | Negative |
Disease | Gene | Description | Result Category |
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SZ | DAOA | In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder. | Positive |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016