Meta-analysis Report

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Basic Info

Reference	Detera-Wadleigh, S. D., 2006 PMID: 16581030
Citation	Detera-Wadleigh, S. D. and F. J. McMahon (2006). "G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis." Biol Psychiatry 60(2): 106-114.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Candidate-gene association study

Detail Info

Samples	11 genetic-association studies: One study was excluded because alleles were not identified in the individual marker analyses. Seven studies focused on schizophrenia or psychosis not otherwise specified, two studies focused on bipolar affective disorder, one study focused on both, and one study focused on panic disorder.
Statistic Method	To accommodate the great variation across studies in the test statistics used and the way in which results were reported, the meta-analysis was performed with the Fisher method, which can combine p values across studies without need of the primary data.
Basic Result	Their meta-analysis of published association studies shows highly significant evidence of association between nucleotide variations in the G72/G30 region and schizophrenia, along with compelling evidence of association with bipolar disorder. But the associated alleles and haplotypes are not identical across studies, and some strongly associated variants are located ~50 kb telomeric of G72. The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 18)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs947267	DAOA DAOA-AS1	A/C	Fisher P-value = 0.2256 for all, P-value = 0.2513 for BP Only		Negative
rs778294	DAOA DAOA-AS1	A/G	Fisher P-value = 0.7598 for all, P-value = 0.8368 for BP Only		Negative
rs954581	DAOA-AS1 DAOA	C/T	Fisher P-value = 0.5966 for all, P-value = 0.8368 for BP Only		Negative
rs746187	DAOA	C/T	Fisher P-value = 0.5966 for all		Negative
rs778293	DAOA	A/G	Fisher P-value = 0.0003 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
rs3918341	DAOA DAOA-AS1	A/G	Fisher P-value = 0.5966 for all		Negative
rs3918342	DAOA	C/T	Fisher P-value = 0.0000 for all, P-value = 0.0309 for BP Only	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More...	Positive
rs3916970	DAOA-AS1 DAOA	A/G	Fisher P-value = 0.5966 for all		Negative
rs3916971	DAOA-AS1 DAOA	C/T	Fisher P-value = 0.0919 for all		Negative
rs3916966	DAOA-AS1 DAOA	A/C	Fisher P-value = 0.0413 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
rs3916967	DAOA DAOA-AS1	A/G	Fisher P-value = 0.0734 for all		Negative
rs3916964	DAOA	C/T	Fisher P-value = 0.1138 for all		Negative
rs3916965	DAOA	A/G	Fisher P-value = 0.0001 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. More...	Positive
rs1935062	DAOA DAOA-AS1	A/C	Fisher P-value = 0.0143 for all, P-value = 0.0019 for BP Only	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More...	Positive
rs2391191	DAOA DAOA-AS1	A/G	Fisher P-value = 0.0000 for all, P-value = 0.2513 for BP Only	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
rs1421292	DAOA	A/T	Fisher P-value = 0.001 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
rs1935058	DAOA-AS1 DAOA	C/T	Fisher P-value = 0.0015 for all, P-value = 0.0153 for BP Only	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value. Only three studies have been published in bipolar-disorder samples, but significant (p<0.05) combined results are seen for three markers spanning more than 74 kb. More...	Positive
rs1341402	DAOA DAOA-AS1	C/T	Fisher P-value = 0.0505 for all, P-value = 0.0832 for BP Only		Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
DAOA	In summary, this meta-analysis supports significant association of markers in the G72 region with bo...... In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs954581	DAOA-AS1 DAOA	Fisher P-value = 0.5966 for all, P-value = 1 for SCZ Only		Negative
SZ	rs947267	DAOA DAOA-AS1	Fisher P-value = 0.2256 for all, P-value = 0.9478 for SCZ Only		Negative
SZ	rs778294	DAOA DAOA-AS1	Fisher P-value = 0.7598 for all, P-value = 0.9373 for SCZ Only		Negative
SZ	rs778293	DAOA	Fisher P-value = 0.0003 for all, P-value = 0.0033 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
SZ	rs3916965	DAOA	Fisher P-value = 0.0001 for all, P-value = 0.0002 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb.	Positive
SZ	rs3916966	DAOA-AS1 DAOA	Fisher P-value = 0.0413 for all, P-value = 0.0683 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
SZ	rs3916967	DAOA DAOA-AS1	Fisher P-value = 0.0734 for all, P-value = 0.0734 for SCZ Only		Negative
SZ	rs3916970	DAOA-AS1 DAOA	Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only		Negative
SZ	rs3916971	DAOA-AS1 DAOA	Fisher P-value = 0.0919 for all, P-value = 0.0919 for SCZ Only		Negative
SZ	rs3918341	DAOA DAOA-AS1	Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only		Negative
SZ	rs3918342	DAOA	Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb.	Positive
SZ	rs746187	DAOA	Fisher P-value = 0.5966 for all, P-value = 0.5966 for SCZ Only		Negative
SZ	rs1341402	DAOA DAOA-AS1	Fisher P-value = 0.0505 for all, P-value = 0.9667 for SCZ Only		Negative
SZ	rs1421292	DAOA	Fisher P-value = 0.001 for all, P-value = 0.0092 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
SZ	rs1935058	DAOA-AS1 DAOA	Fisher P-value = 0.0015 for all, P-value = 0.4416 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
SZ	rs1935062	DAOA DAOA-AS1	Fisher P-value = 0.0143 for all, P-value = 0.9804 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
SZ	rs2391191	DAOA DAOA-AS1	Fisher P-value = 0 for all, P-value = 0.0006 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers and are highly significant (p<0.001) for three markers spanning more than 82 kb.	Positive
SZ	rs3916964	DAOA	Fisher P-value = 0.1138 for all, P-value = 0.1138 for SCZ Only		Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	DAOA	In summary, this meta-analysis supports significant association of markers in the G72 region with both schizophrenia and bipolar affective disorder.	Positive