SNP Report

Basic Info

Name	rs34041110 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG2:1246377 - 1246377(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.49401
Functional Annotation	downstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000264335, ENST00000466227, ENST00000496706, ENST00000571732, ENST00000573026, ENST00000573196, ENST00000575977, ENST00000616643, ENST00000626999, ENST00000627231, ENST00000628059, ENST00000628106, ENST00000629090, ENST00000630606)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, J,2011(b)	A/G		For BD: allele, OR[95%CI]=1.06[0.94-1.20], P-value = 0.3148,...... For BD: allele, OR[95%CI]=1.06[0.94-1.20], P-value = 0.3148, P-permutation=0.9906; genotype, P-value = 0.5442, P-permutation=1 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	17p13.3	1(0/1/0)

SNPs in LD with rs34041110 (count: 11) View in gBrowse (chrCHR_HSCHR17_2_CTG2:1239278..1296957 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs7213824	intron_variant; NMD_transcript_variant	0.907[CHB]; 0.931[CHD]; 0.86[JPT]
rs2131432	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.909[CHB]; 0.882[CHD]
rs7212572	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.868[CHB]
rs9895157	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.909[CHB]
rs7219635	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.868[CHB]; 0.906[CHD]
rs4366768		0.807[CHB]
rs11655176	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.868[CHB]; 0.906[CHD]
rs8067801	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.908[CHB]
rs9748126	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.909[CHB]
rs7212894	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.868[CHB]
rs9912147	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	0.909[CHB]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For SZ:allele, OR[95%CI]=1.05[0.93-1.18], P-value = 0.41938, P-permutation=0.9987;genotype, P-value = 0.62434, P-permutation=1	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For MDD:allele, OR[95%CI]=1.14[1.01-1.29], P-value = 0.02843, P-permutation=0.3244;genotype, P-value = 0.06655, P-permutation=0.5703	No significant association was observed.	Negative