Reference |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result Category |
Ivanova, M. A.,2012 |
Val66Met |
|
Case–control study:C(Val) allele:80.72%/75.95%(case/contro......
Case–control study:C(Val) allele:80.72%/75.95%(case/control); P=0.093; genotype Met/Met:3.07%/6.96%(case/control) for the narrow phenotype.
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No significant association was observed.
No significant association was observed.
|
Negative
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Neves-Pereira, M.,2005 |
G/A |
|
allele: X2=0.377, P-value = 0.54; genotype: P-val......
allele: X2=0.377, P-value = 0.54; genotype: P-value > 0.05
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No significant associations were found in BD.
No significant associations were found in BD.
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Negative
|
Kim, B., 2008 |
|
|
differences in allele (X2 = 0.400, P- value= 0.82......
differences in allele (X2 = 0.400, P- value= 0.821) and genotype (X2= 0.220, P- value = 0.640)
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Allelic distributions did not differ significantly between b......
Allelic distributions did not differ significantly between bipolar patients and controls.
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Negative
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Yosifova, A.,2009 |
C/T |
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Allelic association: 1st screening: P-value = 0.0079, 2nd sc......
Allelic association: 1st screening: P-value = 0.0079, 2nd screening: P-value = 0.14, total: P-value = 0.0033
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Significant association was observed in 1st screening and to......
Significant association was observed in 1st screening and total sample.
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Positive
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Xu, J., 2010 |
Val66Met |
Val |
genotype test: P-value = 0.00884 for all patients, P-value =......
genotype test: P-value = 0.00884 for all patients, P-value = 0.0391 for BD-I patients, P-value = 0.0364 for BD-II patients. Allele test: P-value = 0.425 for all patients, P-value = 0.903 for BD-I patients, P-value = 0.0516 for BD-II patients. The odds ratio for patients with Met/Met was 1.44 (95% CI=1.070-1.950; P=0.016), for those with bipolar I disorder 1.335 (95% CI=0.973-1.832; P=0.146) and for those with bipolar II disorder 2.07 (95% CI=1.242-3.454; P=0.011), respectively.
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the Met allele rather than the Val allele increased the risk......
the Met allele rather than the Val allele increased the risk for BPD in our Han population.
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Positive
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Kanazawa, T., 2007 |
Val(G)/Met(A) |
Met |
P-value = 0.161, OR=0.95 (95% CI: 0.88-1.02), z=1.40, hetero......
P-value = 0.161, OR=0.95 (95% CI: 0.88-1.02), z=1.40, heterogeneity P-value = 0.769, X2=6.53 (d.f.=10) for bipolar disorder
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The data showed stronger evidence for association but still ......
The data showed stronger evidence for association but still did not attain significance. No evidence of heterogeneity was observed among these studies
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Negative
|
Gonzalez-Castro, T. B., 2014 |
|
|
Meta-analysis: Val allele: with heterogeneity: random effect......
Meta-analysis: Val allele: with heterogeneity: random effects: OR=1.06, 95%CI=0.95-1.18, P-value=0.31; without heterogeneity: random effects: OR=1.02; 95%CI=0.97-1.08; P-value=0.38. Met allele: with heterogeneity: random effects: OR=0.93, 95%CI=0.84-1.04, P-value=0.31; without heterogeneity: random effects: OR=0.97, 95%CI=0.92-1.03, P-value=0.38. Caucasian: with heterogeneity: random effects: OR=1.11, 95%CI=0.90-1.38, P-value=0.59; without heterogeneity: random effects: OR=1.03, 95%CI=0.94-1.12, P-value=0.91. Asian: without heterogeneity: random effects: OR=0.99, 95%CI=0.92-1.06, P-value=0.21. Additive model: with heterogeneity: random effects: OR=1.06, 95%CI=0.91-1.23, P-value=0.49; without heterogeneity: random effects: OR=1.01, 95%CI=0.89-1.14, P-value=0.73. Dominant model: with heterogeneity: random effects: OR=1.07, 95%CI=0.93-1.22, P-value=0.23; without heterogeneity: random effects: OR=1.05, 95%CI=0.93-1.18, P-value=0.54. Recessive model: with heterogeneity: random effects: OR=1.02, 95%CI=0.93-1.12, P-value=0.46; without heterogeneity: random effects: OR=1.04, 95%CI=0.96-1.13, P-value=0.15. Case-control study: BDNF Val66Met genotype groups: P-value=0.84; Allele groups: P-value=0.55, OR=0.87, 95%CI=0.56-1.35
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No significant associations were observed in all models and ......
No significant associations were observed in all models and subgroups.
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Negative
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Seifuddin, F.,2012 |
C/T |
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Meta-analysis OR=0.93, 95% CI=0.87-1.00, P-value = 0.050
Meta-analysis OR=0.93, 95% CI=0.87-1.00, P-value = 0.050
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No significance was found after correction for multiple test......
No significance was found after correction for multiple testing.
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Negative
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Liu, L., 2008 |
|
|
Average PDT statistic P-value = 0.4 for the model 1; averag......
Average PDT statistic P-value = 0.4 for the model 1; average PDT statistic P-value = 0.26 for the model 2; average PDT statistic P-value = 0.06 for the model 3 between the SNP and bipolar disorder.
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The previously reported Val66Met polymorphism (rs6265) was n......
The previously reported Val66Met polymorphism (rs6265) was not significantly associated with either bipolar disorder or rapid cycling
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Negative
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Oswald, P., 2004 |
G>A |
|
X2 (df=2)=2.0, P-value = 0.37 for genotypes; X
X2 (df=2)=2.0, P-value = 0.37 for genotypes; X2 (df=1)=0.00, P-value = 0.94 for alleles distributions
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No significant differences were found in the frequency of ge......
No significant differences were found in the frequency of genotypes and alleles between controls and BPAD patients
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Negative
|
Lohoff, F. W.,2005(c) |
Val/Met |
Val |
chi-square test: genotype P-value = 0.062, allele P-value = ......
chi-square test: genotype P-value = 0.062, allele P-value = 0.028
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Significant associations were found in allele frequencies .
Significant associations were found in allele frequencies .
|
Positive
|
Sears, C.,2011 |
|
A |
FBAT: MAF=0.173, P-value = 0.04
FBAT: MAF=0.173, P-value = 0.04
|
Significant association was found .
Significant association was found .
|
Positive
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Hosang, G. M.,2010 |
Val66Met |
Met |
X2 test: Genotypic distribution, X2=15......
X2 test: Genotypic distribution, X2=15.65, df=2, P-value = 0.001
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Significant association was found in BD.
Significant association was found in BD.
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Positive
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Kremeyer, B., 2006 |
A/G |
|
P-value = 0.001, X2=10.77, df=1
P-value = 0.001, X2=10.77, df=1
|
At the Val66Met polymorphism there is a significant over-tra......
At the Val66Met polymorphism there is a significant over-transmission of the Val allele.
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Positive
|
Wang, Z.,2012 |
Val66Met |
Met |
genotype: X2 = 6.18, df = 2, P =0.046; allele: X......
genotype: X2 = 6.18, df = 2, P =0.046; allele: X2 = 5.01, df = 1, P-value = 0.025
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Val66Met is associated with BD
Val66Met is associated with BD
|
Positive
|
Schumacher, J.,2005 |
G/A |
|
Armitage Trend Test: in Bonn sample, for BPAD, P-value(odds ......
Armitage Trend Test: in Bonn sample, for BPAD, P-value(odds ratio)=0.924(1.01)
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No significant association was observed.
No significant association was observed.
|
Negative
|
Neves, F. S.,2011 |
T/C |
|
chi-square test: allele, P-value = 0.474, OR(95%CI)=0.83(0.5......
chi-square test: allele, P-value = 0.474, OR(95%CI)=0.83(0.50-1.37), genotype, P-value = 0.123
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No significant association was observed.
No significant association was observed.
|
Negative
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