Gene Report

Approved Symbol	PBRM1
Symbol Alias	BAF180, PB1
Approved Name	polybromo 1
Location	3p21
Position	chr3:52545352-52685917, -1
External Links	HGNC: 30064 Entrez Gene: 55193 Ensembl: ENSG00000163939 UCSC: uc003dey.2
No. of Studies	5 (Positive: 4; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00856, Product of P truncation <=0.01=0.00246, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study
Green, E. K.,2012	SNP: rs3755806	BD ImmunoChip:P-value = 0.0222,OR = 0.891;ImmunoChip, PGC-BD combined data:P-balue = 0.000000421,OR = 0.889 Suggestive association was found.	Trend	Comment on Study
Vassos, E.,2012	SNP: rs2251219	There is strong evidence of association of rs2251219 with BP. However, our data do not support association of this marker with schizophrenia. Because the region of association has high linkage disequilibrium, forming a large haplotype block across many genes, it is not clear which gene is causally implicated in the disorder.	Positive	Comment on Study
Kondo, K.,2013	SNP: rs2251219	Significant association was observed.	Positive	Comment on Study
McMahon, F. J., 2010	SNP: rs2251219	A synonymous variant rs2251219 in the gene PBRM1 was significant in major mood disorders.	Positive	Comment on Study

Region: chr3:52545352..52685917 View in gBrowse