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SNP Report
Basic Info
| Name | rs7004633 dbSNP Ensembl |
|---|---|
| Location | chr8:88748082 - 88748082(1) |
| Variant Alleles | A/G |
| Ancestral Allele | A |
| Minor Allele | G |
| Minor Allele Frequence | 0.317292 |
| No. of Studies | 2 (Positive: 1; Negative: 1; Trend: 0) |
| Source | Literature |
| Overlap with SZ? | YES |
| Overlap with MDD? | NO |
SNP related studies (count: 2)
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 8q21 | 1(0/1/0) |
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.
Literature-origin SNPs (count: 0)
LD-proxies (count: 2)
Overlap with SZ from cross-disorder studies (count: 2)
| Reference | Statistical Result | Description | Result Category |
|---|---|---|---|
| Andreassen OA, 2013 | Conditional FDR; SCZ loci given BD: P-value=0.00000017, FDR=0.018, FDR=0.005 for SCZ and BD | To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. | Positive |
| Saito T., 2014 | First-set screening: P-valuecorrected=0.65, P-value=0.0155, OR=0.83, 95%CI=0.71-0.96 | Significant association was observed. | Positive |
Overlap with MDD from cross-disorder studies (count: 0)