BDgene

SNP Report

Basic Info
Name rs7004633 dbSNP Ensembl
Location chr8:88748082 - 88748082(1)
Variant Alleles A/G
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.317292
No. of Studies 2 (Positive: 1; Negative: 1; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Andreassen OA, 2013 Conditional FDR; SCZ loci given BD: FDR=0.005 for SCZ and BD Conditional FDR; SCZ loci given BD: FDR=0.005 for SCZ and BD To estimate the number of independent loci, we 'pruned' the ...... To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. More... Positive
Saito T., 2014 G/A First-set screening: P-valuecorrected=1, P-value=...... First-set screening: P-valuecorrected=1, P-value=0.384, OR=0.93, 95%CI=0.80-1.09 More... No significant association was observed. No significant association was observed. Negative

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MMP16 matrix metallopeptidase 16 (membrane-inserted) 8q21 1(0/1/0)

SNPs in LD with rs7004633 (count: 2) View in gBrowse (chr8:88748082..88748700 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)


Overlap with SZ from cross-disorder studies (count: 2)
Reference Statistical Result Description Result Category
Andreassen OA, 2013 Conditional FDR; SCZ loci given BD: P-value=0.00000017, FDR=0.018, FDR=0.005 for SCZ and BD To estimate the number of independent loci, we 'pruned' the associated SNPs (removed SNPs with linkage disequilibrium (LD)>0.2), and identified a total of 58 independent loci with a significance threshold of conditional FDR<0.32. Positive
Saito T., 2014 First-set screening: P-valuecorrected=0.65, P-value=0.0155, OR=0.83, 95%CI=0.71-0.96 Significant association was observed. Positive

Overlap with MDD from cross-disorder studies (count: 0)