SNP Report

Basic Info

Name	rs7224258 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG2:1254987 - 1254987(1)
Variant Alleles	G/C
Ancestral Allele	G
Minor Allele	C
Minor Allele Frequence	0.274361
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000264335, ENST00000466227, ENST00000496706, ENST00000571732, ENST00000573026, ENST00000573196, ENST00000575977); NMD_transcript_variant(ENST00000466227, ENST00000573196); non_coding_transcript_exon_variant(ENST00000623383); non_coding_transcript_variant(ENST00000623383, ENST00000616643, ENST00000626999, ENST00000627231, ENST00000628059, ENST00000628106, ENST00000629090, ENST00000630606, ENST00000629090, ENST00000630606)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	YES

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Liu, J,2011(b)	G/T		For BD: allele, OR[95%CI]=0.99[0.86-1.14], P-value = 0.8813,...... For BD: allele, OR[95%CI]=0.99[0.86-1.14], P-value = 0.8813, P-permutation=1; genotype, P-value = 0.4687, P-permutation=1 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	17p13.3	1(0/1/0)

SNPs in LD with rs7224258 (count: 1) View in gBrowse (chrCHR_HSCHR17_2_CTG2:1254987..1309718 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs7213805			0.936[CHB]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For SZ:allele, OR[95%CI]=0.92[0.83-1.07], P-value = 0.30125, P-permutation=0.9862;genotype, P-value = 0.27691, P-permutation=0.9789	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Liu, J,2011(b)	For MDD:allele, OR[95%CI]=1.02[0.89-1.17], P-value = 0.81025, P-permutation=1;genotype, P-value = 0.77061, P-permutation=1	No significant association was observed.	Negative