SNP Report

Basic Info

Name	rs1421292 dbSNP Ensembl
Location	chr13:105545886 - 105545886(1)
Variant Alleles	T/A
Ancestral Allele	T
Minor Allele	A
Minor Allele Frequence	0.370407
No. of Studies	8 (Positive: 2; Negative: 6; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 8)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Maheshwari, M.,2009	A/T		TDT: Raw TDT P-value = 0.942, Adaptive permutation corrected...... TDT: Raw TDT P-value = 0.942, Adaptive permutation corrected P-value = 0.429 More...	No significant allelic association with BP was found No significant allelic association with BP was found	Negative
Gaysina, D.,2010	A/T		chi-squared tests: allele P-value = 0.66 for UK sample; alle...... chi-squared tests: allele P-value = 0.66 for UK sample; allele P-value = 0.89 for Canadian sample. More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Bass, N. J.,2009	A/T		chi-squared tests: for BP, allele, X²(1 d.f.)=2.3...... chi-squared tests: for BP, allele, X²(1 d.f.)=2.337, P-value = 0.126; for BP+SCZ, allele, X²(1 d.f.)=4.059, P-value = 0.044 More...	Association was not observed in allelic association in BP, b...... Association was not observed in allelic association in BP, but was observed in BP+SCZ samples. More...	Negative
Grigoroiu-Serbanescu, M.,2010	T/A		Allelic association analysis: for non-psychotic patients, P-...... Allelic association analysis: for non-psychotic patients, P-value = 0.342, OR(95%CI)=0.75(0.42-1.37); for psychotic patients, P-value = 0.598, OR(95%CI)=1.09(0.80-1.47) More...	No significant association was observed in BD. No significant association was observed in BD.	Negative
Zuliani, R.,2009	A/T		Reductions in left temporal lobe pole gray matter[voxel leve...... Reductions in left temporal lobe pole gray matter[voxel level, T=5.30, pFW =0.019, peak MNI coordinates= (-40, 12, -29)]using the temporal lobe SVC.Post-hoc analyses : genotype-by-group interaction in the temporal lobe for M24 (F=3.66, p=0.029). More...	Genetic variation at both the M24 loci in G72 were associate...... Genetic variation at both the M24 loci in G72 were associated with decreased gray matter density within the left temporal pole in people with bipolar disorder.The genetic imaging associations were found only in patients with bipolar disorder. More...	Positive
Schulze, T. G.,2005	A/T	T	For German group : All Patients With Bipolar Affective Disor...... For German group : All Patients With Bipolar Affective Disorder, P-value > 0.05 , OR=1.24, 95CI=0.98-1.56.Patients With a History of Psychotic Symptoms, P-value > 0.05 , OR=1.29, 95CI=0.98-1.69. Patients With No History of Psychotic Symptoms, P-value > 0.05 , OR=0.98, 95CI=0.69-1.40.For Polish group: All Patients With Bipolar Affective Disorder, P-value > 0.05 , OR=1, 95CI=0.80-1.27.Patients With a History of Psychotic Symptoms, P-value > 0.05 , OR=0.95, 95CI=0.70-1.28. Patients With No History of Psychotic Symptoms, P-value > 0.05 , OR=1.22, 95CI=0.81-1.86 More...	No significant association was observed. No significant association was observed.	Negative
Detera-Wadleigh, S. D., 2006	A/T		Fisher P-value = 0.001 for all Fisher P-value = 0.001 for all	When results are combined across studies and phenotypes, thi...... When results are combined across studies and phenotypes, this marker showed significant combined p value More...	Positive
Williams, N. M., 2006			allelic P-value = 0.59, Gene-wide test P-value = 0.045 in Bi...... allelic P-value = 0.59, Gene-wide test P-value = 0.045 in Bipolar I Disorder More...	We observed significant evidence for whole-gene association ...... We observed significant evidence for whole-gene association (P=.04). More...	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
DAOA	D-amino acid oxidase activator	13q33.2	21(13/7/1)

SNPs in LD with rs1421292 (count: 21) View in gBrowse (chr13:105511865..105545886 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 21)

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs9301038			0.924[CEU]
rs9519694			0.928[CEU]
rs4267180			1.0[CEU]
rs9519697			0.928[CEU]
rs7327655			1.0[CEU]
rs1981272			0.924[CEU]
rs1549056			1.0[CEU]
rs9519693			0.927[CEU]
rs1981271			0.924[CEU]
rs7329771			1.0[CEU]
rs1362886			0.959[CEU]
rs1549057			1.0[CEU]
rs9586884			1.0[CEU]
rs7329787			0.849[CEU]
rs2052382			1.0[CEU]
rs9519714			1.0[CEU]
rs866973			1.0[CEU]
rs7993649			1.0[CEU]
rs9519707			0.853[CEU]
rs7331815			0.819[CEU]
rs16966753			0.928[CEU]

Overlap with SZ from cross-disorder studies (count: 3)

Reference	Statistical Result	Description	Result Category
Williams, N. M., 2006	allelic P-value = 0.66 in Schizophrenia	We found no evidence for allelic or genotypic association with any of the polymorphisms studied for schizophrenia. We observed nominally significant evidence (P=.01-.047) for allelic association with 3 of the polymorphisms for bipolar disorder and significant evidence for whole-gene association (P=.04).	Negative
Detera-Wadleigh, S. D., 2006	Fisher P-value = 0.001 for all, P-value = 0.0092 for SCZ Only	When results are combined across studies and phenotypes, this marker showed significant combined p value. Combined results in schizophrenia are significant for several markers.	Positive
Bass, N. J.,2009	chi-squared tests:for SCZ, allele, X²(1 d.f.)=3.499, P-value = 0.062	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 0)