BDgene

SNP Report

Basic Info
Name rs133068 dbSNP Ensembl
Location chr22:40678403 - 40678403(1)
Variant Alleles G/C
Ancestral Allele C
Minor Allele G
Minor Allele Frequence 0.336661
Functional Annotation upstream_gene_variant.
Consequence to Transcript upstream_gene_variant(ENST00000249016, ENST00000381433, ENST00000442317, ENST00000465662, ENST00000498400)
No. of Studies 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature
Overlap with SZ? YES
Overlap with MDD? NO

SNP related studies (count: 2)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Severinsen, J. E., 2006 (a) C/G CLUMP T1 P-value = 0.8365, CLUMP T4 P-value = 0.8365 for BPD...... CLUMP T1 P-value = 0.8365, CLUMP T4 P-value = 0.8365 for BPD; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6757 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland More... Negative
Yosifova, A.,2009 C/G Allelic association: P-value = 0.46 Allelic association: P-value = 0.46 No significant association was observed No significant association was observed Negative

SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
MCHR1 melanin-concentrating hormone receptor 1 22q13.3 2(1/1/0)
GAPDHP37 glyceraldehyde 3 phosphate dehydrogenase pseudogene 37 22q13.2 Mapped by Literature SNP

SNPs in LD with rs133068 (count: 4) View in gBrowse (chr22:40670883..40679539 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Severinsen, J. E., 2006 (a) CLUMP T1 P-value = 0.0197, CLUMP T4 P-value = 0.0197 for SZ; CLUMP T1 P-value = 0.1461, CLUMP T4 P-value = 0.1461 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.8145 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.8538 for BPD and SZ in the Case-Control Sample From Scotland The three GPR24 SNPs rs133068, rs133069, and rs133073 showed association with SZ yielding P-values of 0.008-0.02. Positive

Overlap with MDD from cross-disorder studies (count: 0)