SNP Report

Basic Info

Name	rs901561 dbSNP Ensembl
Location	chr8:32285946 - 32285946(1)
Variant Alleles	G/A/T
Ancestral Allele	A
Minor Allele	G
Minor Allele Frequence	0.241414
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000517967, ENST00000518104, ENST00000519301, ENST00000520407, ENST00000523320, ENST00000523534, ENST00000631040); non_coding_transcript_variant(ENST00000517967, ENST00000523320)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Goes, F. S., 2009		G	FBAT: additive model, individual P-value = 0.0451(Standard B...... FBAT: additive model, individual P-value = 0.0451(Standard BP), 0.0279(Psychotic BP), 0.425(Mood-incongruent psychotic BP); dominant model, individual P-value = 0.0523(Standard BP), 0.0061(Psychotic BP), 0.386(Mood-incongruent psychotic BP) More...	Significant association was observed in both standard BP and...... Significant association was observed in both standard BP and Psychotic BP. More...	Positive
Thomson, P. A., 2007			Individual P-value = 0.9317 for BP, Individual P-value = 0.9...... Individual P-value = 0.9317 for BP, Individual P-value = 0.9163 for SCZ and BP More...		Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs901561 (count: 2) View in gBrowse (chr8:32283999..32298269 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs7824399		intron_variant; non_coding_transcript_variant	1.0[CEU]
rs4236707		intron_variant	1.0[CEU]; 0.946[TSI]

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Thomson, P. A., 2007	Individual P-value = 0.7958 for SCZ , Individual P-value = 0.9163 for SCZ and BP		Negative

Overlap with MDD from cross-disorder studies (count: 0)