SNP Report

Basic Info

Name	rs909669 dbSNP Ensembl
Location	chr22:40346413 - 40346413(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.209465
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000216194, ENST00000342312, ENST00000466863, ENST00000477111, ENST00000623063, ENST00000623287, ENST00000623632, ENST00000623978, ENST00000624474, ENST00000624503, ENST00000636124, ENST00000636265, ENST00000636714, ENST00000637666, ENST00000637669, ENST00000638161)
No. of Studies	2 (Positive: 1; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	YES
Overlap with MDD?	NO

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Yosifova, A.,2009	C/T		Allelic association: P-value = 0.65 Allelic association: P-value = 0.65	No significant association was observed No significant association was observed	Negative
Severinsen, J. E., 2006 (a)	C/T		CLUMP T1 P-value = 0.0373, CLUMP T4 P-value = 0.0373 for BPD...... CLUMP T1 P-value = 0.0373, CLUMP T4 P-value = 0.0373 for BPD; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.6833 for BPD in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland More...	In BPD and BPD/SZ combined, single marker association was ob...... In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ADSL	adenylosuccinate lyase	22q13.1	2(1/1/0)

SNPs in LD with rs909669 (count: 0) View in gBrowse (chr22:40346413..40346413 )

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Severinsen, J. E., 2006 (a)	CLUMP T1 P-value = 0.1178, CLUMP T4 P-value = 0.1178 for SZ; CLUMP T1 P-value = 0.0036, CLUMP T4 P-value = 0.0036 for BPD and SZ in the Faeroese Sample; Empirical overall P-value = 0.0655 for SZ in the Case-Control Sample From Scotland; Empirical overall P-value = 0.2189 for BPD and SZ in the Case-Control Sample From Scotland	In BPD and BPD/SZ combined, single marker association was observed for rs909669 (ADSL) and rs133070 (GPR24) with P-values between 0.0036 and 0.037.	Positive

Overlap with MDD from cross-disorder studies (count: 0)