Gene Report

Basic Info
Approved Symbol NT5C2
Previous Symbol NT5B
Symbol Alias PNT5, GMP, cN-II, SPG65
Approved Name 5'-nucleotidase, cytosolic II
Previous Name 5'-nucleotidase (purine), cytosolic type B
Name Alias purine 5' nucleotidase
Location 10q24.32
Position chr10:103088017-103193306, -1
External Links HGNC: 8022
Entrez Gene: 22978
Ensembl: ENSG00000076685
UCSC: uc001kwq.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hamshere, M. L.,2012 SNP: rs11191580 We also provide strong evidence for overlap in genetic risk between schizophrenia and bipolar disorder. Positive Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 SNP: rs11191580 Significant association was observed in cross-disorder analysis. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 0)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 17)

Literature-origin SNPs (count: 1)

LD-proxies (count: 16)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr10:103088017..103193306 View in gBrowse
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