Study Report

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Basic Info

Reference	Lee, K. Y., 2006 (a) PMID: 16491131
Citation	Lee, K. Y., Y. M. Ahn, et al. (2006). "The association of DUSP6 gene with schizophrenia and bipolar disorder: its possible role in the development of bipolar disorder." Mol Psychiatry 11(5): 425-426.
Disease Type	Bipolar Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	132 bipolar subjects, 160 schizophrenics and 336 healthy controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Mongloid
Population	Korean

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	All were unrelated Koreans and all patients met DSM-IV criteria for bipolar disorder or schizophrenia. All patients were interviewed with the Korean version of Diagnostic Interview for Genetic Studies and the diagnoses were made through diagnostic consensus meeting.
Technique	genotyping using TaqMan
Statistical Method	Chi square tests were used to compare allele frequencies and genotype distributions between each groups of controls and patients. They assumed that the less frequent allele contributed to bipolar disorder and schizophrenia and set the significance level to P=0.05, whereby obtaining the powers of 78.0 and 90.0% (OR=2.0; mode of inheritance: dominant), respectively.
Result Summary	G allele was significantly more common in bipolar patients than controls (OR=1.382, 95% CI 1.037-1.843), but there was no difference between schizophrenic patients and controls. G allele frequency was also significantly increased in female bipolar patients compared to female controls (OR=1.699, 95% CI 1.139-2.444), but there was no group difference in males. When allele (P=0.067) and genotype distribution (P=0.140) were compared between the bipolar and schizophrenia groups, no significant difference was found. However, G allele was observed more commonly in bipolar females than their schizophrenic counterparts (OR=1.780, 95% CI 1.083-2.927). Our evidence derived from the case-control-based sample set suggests an association of DUSP6 gene with bipolar disorder but not with schizophrenia.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs2279574	DUSP6	T/G		allelic P-value = 0.027, genotypic P-value = 0.062 for total patients; allelic P-value = 0.691, genotypic P-value = 0.52 for male patients; allelic P-value = 0.008, genotypic P-value = 0.02 for female patients with bipolar disorder	G allele was significantly more common in bipolar patients t...... G allele was significantly more common in bipolar patients than controls. G allele frequency was also significantly increased in female bipolar patients compared to female controls , but there was no group difference in males. When allele and genotype distribution were compared between the bipolar and schizophrenia groups, no significant difference was found. However, G allele was observed more commonly in bipolar females than their schizophrenic counterparts. More...	Positive

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
DUSP6	In conclusion, our results demonstrated for the first time that in the Korean population DUSP6 gene ...... In conclusion, our results demonstrated for the first time that in the Korean population DUSP6 gene may contribute to the etiology of bipolar disorder, but not to schizophrenia. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs2279574	DUSP6	allelic P-value = 0.911, genotypic P-value = 0.991 for total patients; allelic P-value = 0.95, genotypic P-value = 0.865 for male patients; allelic P-value = 0.776, genotypic P-value = 0.95 for female patients with schizophrenia	G allele was not different between schizophrenic patients and controls. When allele and genotype distribution were compared between the bipolar and schizophrenia groups, no significant difference was found. However, G allele was observed more commonly in bipolar females than their schizophrenic counterparts.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	DUSP6	In conclusion, our results demonstrated for the first time that in the Korean population DUSP6 gene may contribute to the etiology of bipolar disorder, but not to schizophrenia.	Negative