BD & SZ shared genes

Total unique gene count: 471

From cross-disorder studies (count: 324)
Approved Symbol Approved Name Location No. of Studies for BD (Positive/Negative/Trend) Overlap with SZ Overlap with MDD Help
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 44(18/26/0) YES YES
BDNF brain-derived neurotrophic factor 11p14.1 37(24/12/1) YES YES
COMT catechol-O-methyltransferase 22q11.21 28(14/14/0) YES YES
DRD2 dopamine receptor D2 11q22-q23 28(8/20/0) YES YES
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0) YES YES
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1) YES YES
MAOA monoamine oxidase A Xp11.4-p11.3 21(10/11/0) YES YES
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0) YES YES
DRD3 dopamine receptor D3 3q13.3 19(4/15/0) YES YES
DISC1 disrupted in schizophrenia 1 1q42.1 18(10/7/1) YES YES
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 17(13/3/1) YES YES
TH tyrosine hydroxylase 11p15.5 16(4/12/0) YES YES
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1p36.3 16(10/6/0) YES YES
NRG1 neuregulin 1 8p12 15(10/5/0) YES YES
TPH1 tryptophan hydroxylase 1 11p15.3-p14 14(5/9/0) YES YES
DRD4 dopamine receptor D4 11p15.5 13(1/12/0) YES YES
CLOCK clock circadian regulator 4q12 12(5/7/0) YES YES
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0) YES YES
DRD1 dopamine receptor D1 5q34-q35 11(6/5/0) YES YES
GSK3B glycogen synthase kinase 3 beta 3q13.3 8(0/8/0) YES YES
DTNBP1 dystrobrevin binding protein 1 6p22.3 8(4/3/1) YES YES
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 8(2/5/1) YES YES
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p13.1 8(4/4/0) YES YES
PER2 period circadian clock 2 2q37.3 7(1/6/0) YES YES
GRM3 glutamate receptor, metabotropic 3 7q21.1-q21.2 7(3/4/0) YES YES
PER3 period circadian clock 3 1p36.23 7(3/4/0) YES YES
ARNTL aryl hydrocarbon receptor nuclear translocator-like 11p15 7(5/2/0) YES YES
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1q21.3 7(1/6/0) YES YES
ZNF804A zinc finger protein 804A 2q32.1 6(3/3/0) YES NO
SYNE1 spectrin repeat containing, nuclear envelope 1 6q25.2 6(3/2/1) YES YES
NR1D1 nuclear receptor subfamily 1, group D, member 1 17q11.2 6(2/4/0) YES YES
TENM4 teneurin transmembrane protein 4 11q13 6(4/2/0) YES YES
RGS4 regulator of G-protein signaling 4 1q23.3 6(3/2/1) YES YES
DGKH diacylglycerol kinase, eta 13q13.3 6(3/3/0) YES YES
TCF4 transcription factor 4 18q21.1 6(1/5/0) YES NO
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 7p22 5(1/2/2) YES NO
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 22q13.33 5(1/4/0) YES YES
PALB2 partner and localizer of BRCA2 16p12.1 5(2/2/1) YES NO
TAAR6 trace amine associated receptor 6 6q23.1 5(4/1/0) YES YES
NPAS2 neuronal PAS domain protein 2 2q11.2 5(3/2/0) YES YES
PDLIM5 PDZ and LIM domain 5 4q22 5(4/1/0) YES YES
CSNK1E casein kinase 1, epsilon 22q13.1 5(1/3/1) YES YES
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 5(0/5/0) YES YES
PBRM1 polybromo 1 3p21 5(4/0/1) YES YES
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 7p12.1 5(2/3/0) YES YES
FKBP5 FK506 binding protein 5 6p21.31 5(1/4/0) YES YES
ACE angiotensin I converting enzyme 17q23.3 5(2/3/0) YES YES
DAO D-amino-acid oxidase 12q24.11 5(1/4/0) YES NO
CRY2 cryptochrome circadian clock 2 11p11.2 5(3/2/0) YES YES
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 3p22.2 5(2/1/2) YES NO
PER1 period circadian clock 1 17p13.1 5(2/3/0) YES YES
DUSP6 dual specificity phosphatase 6 12q22-q23 5(3/2/0) YES YES
ERDA1 expanded repeat domain, CAG/CTG 1 17q21.3 4(0/4/0) YES NO
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 19p13.3 4(0/3/1) YES NO
TSNAX translin-associated factor X 1q42.2 4(3/1/0) YES YES
TNF tumor necrosis factor 6p21.3 4(2/2/0) YES YES
CSNK1D casein kinase 1, delta 17q25 4(2/2/0) YES YES
PRODH proline dehydrogenase (oxidase) 1 22q11.2 4(0/4/0) YES NO
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0) YES YES
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 18p11.2 4(2/2/0) YES NO
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 10p12.2 4(1/3/0) YES NO
RORB RAR-related orphan receptor B 9q22 4(3/1/0) YES YES
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 8p21 3(0/3/0) YES NO
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 22q11.21 3(1/2/0) YES NO
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0) YES NO
TSPO translocator protein (18kDa) 22q13.3 3(1/2/0) YES YES
BHLHE41 basic helix-loop-helix family, member e41 12p12.1 3(2/1/0) YES YES
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 22q12.1-q13.1 3(2/0/1) YES NO
SNAP29 synaptosomal-associated protein, 29kDa 22q11.21 3(1/2/0) YES NO
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 3(2/1/0) YES YES
SYNGR1 synaptogyrin 1 22q13 3(2/1/0) YES NO
TIMELESS timeless circadian clock 12q13.3 3(0/3/0) YES YES
PDE4B phosphodiesterase 4B, cAMP-specific 1p31 3(1/2/0) YES YES
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 3(1/2/0) YES YES
DBP D site of albumin promoter (albumin D-box) binding protein 19q13.33 3(0/3/0) YES YES
DFNB31 deafness, autosomal recessive 31 9q32 3(2/1/0) YES NO
C15orf53 chromosome 15 open reading frame 53 15q14 3(0/1/2) YES NO
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q11.2-q13 3(2/1/0) YES YES
GPR50 G protein-coupled receptor 50 Xq28 3(2/1/0) YES YES
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 15q24 3(2/1/0) YES NO
EGR3 early growth response 3 8p23-p21 3(2/1/0) YES YES
RELN reelin 7q22 3(1/2/0) YES NO
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 18p11 3(1/2/0) YES YES
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 15q24 3(1/2/0) YES NO
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 12p12.2-p11.2 3(1/2/0) YES YES
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3p21.1 3(3/0/0) YES YES
XBP1 X-box binding protein 1 22q12.1 3(2/1/0) YES YES
DPP10 dipeptidyl-peptidase 10 (non-functional) 2q14.1 3(2/1/0) YES NO
TDRD9 tudor domain containing 9 14q32.33 3(1/1/1) YES NO
EGR2 early growth response 2 10q21.1 3(1/2/0) YES NO
NCAM1 neural cell adhesion molecule 1 11q23.2 3(2/1/0) YES YES
LMO3 LIM domain only 3 (rhombotin-like 2) 12p13 3(2/1/0) YES NO
SP8 Sp8 transcription factor 7p21.2 3(2/0/1) YES YES
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 8p11.21 3(1/2/0) YES NO
ADRA1A adrenoceptor alpha 1A 8p21.2 2(0/2/0) YES NO
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1q43 2(1/1/0) YES NO
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 3p21.1 2(2/0/0) YES YES
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 3p22.2 2(1/1/0) YES NO
TSPAN8 tetraspanin 8 12q14.1-q21.1 2(1/0/1) YES NO
TUBA8 tubulin, alpha 8 22q11 2(1/1/0) YES NO
MCHR1 melanin-concentrating hormone receptor 1 22q13.3 2(1/1/0) YES NO
TIPIN TIMELESS interacting protein 15q22.31 2(0/2/0) YES YES
NPTX1 neuronal pentraxin I 17q25.3 2(1/1/0) YES NO
KLHDC1 kelch domain containing 1 14q21.3 2(1/0/1) YES NO
SLCO3A1 solute carrier organic anion transporter family, member 3A1 15q26 2(1/1/0) YES YES
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 14q24 2(1/1/0) YES NO
CSNK2A1 casein kinase 2, alpha 1 polypeptide 20p13 2(0/2/0) YES YES
RSRC2 arginine/serine-rich coiled-coil 2 12q24.31 2(1/1/0) YES NO
AANAT aralkylamine N-acetyltransferase 17q25.1 2(0/2/0) YES YES
GRM4 glutamate receptor, metabotropic 4 6p21.3 2(2/0/0) YES NO
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 17q24 2(1/1/0) YES NO
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 15q26 2(2/0/0) YES NO
DGCR8 DGCR8 microprocessor complex subunit 22q11.2 2(1/0/1) YES NO
IL1RN interleukin 1 receptor antagonist 2q14.2 2(2/0/0) YES NO
KIF13A kinesin family member 13A 6p23 2(0/1/1) YES NO
FOXP2 forkhead box P2 7q31 2(0/2/0) YES YES
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2q37.3 2(1/0/1) YES NO
KCTD12 potassium channel tetramerization domain containing 12 13q21 2(0/1/1) YES YES
GRIK4 glutamate receptor, ionotropic, kainate 4 11q23.3 2(1/1/0) YES NO
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 7p12.3 2(2/0/0) YES YES
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 2(1/1/0) YES YES
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 12p13 2(1/1/0) YES YES
LMAN2L lectin, mannose-binding 2-like 2q11.1 2(2/0/0) YES NO
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 13q12-q13 2(0/2/0) YES NO
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 2(0/2/0) YES NO
RPTOR regulatory associated protein of MTOR, complex 1 17q25.3 2(1/1/0) YES NO
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0) YES YES
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 15q24 2(1/1/0) YES NO
GPR78 G protein-coupled receptor 78 4p16.1 2(2/0/0) YES NO
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 16q12.2 2(0/2/0) YES YES
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 10q22.2 2(1/1/0) YES NO
GRN granulin 17q21.32 2(2/0/0) YES NO
BRD1 bromodomain containing 1 22q13.33 2(2/0/0) YES NO
ATXN1 ataxin 1 6p23 2(1/1/0) YES NO
DPYSL2 dihydropyrimidinase-like 2 8p22-p21 2(1/0/1) YES NO
MYO18B myosin XVIIIB 22q12.1 2(0/2/0) YES YES
ADSL adenylosuccinate lyase 22q13.1 2(1/1/0) YES NO
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2q31 2(1/1/0) YES YES
TPP2 tripeptidyl peptidase II 13q32-q33 2(1/1/0) YES NO
IL2RB interleukin 2 receptor, beta 22q13 2(1/1/0) YES NO
JAM3 junctional adhesion molecule 3 11q25 2(1/1/0) YES NO
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 11q23.1 2(1/1/0) YES YES
FABP3 fatty acid binding protein 3, muscle and heart 1p33-p32 2(1/1/0) YES NO
NPAS3 neuronal PAS domain protein 3 14q13.1 2(1/1/0) YES YES
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2q33 2(1/1/0) YES YES
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 11q23.1-q23.2 2(1/1/0) YES NO
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 22q12.3 2(1/1/0) YES YES
FBXO38 F-box protein 38 5q33.1 2(1/0/1) YES NO
GFRA1 GDNF family receptor alpha 1 10q25-q26 2(1/1/0) YES NO
NFIL3 nuclear factor, interleukin 3 regulated 9q22 2(0/2/0) YES YES
ZNF274 zinc finger protein 274 19q13.43 2(1/1/0) YES NO
AKR1D1 aldo-keto reductase family 1, member D1 7q32-q33 2(0/1/1) YES NO
FGFR2 fibroblast growth factor receptor 2 10q25.3-q26 2(1/1/0) YES YES
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 11q24.2 2(0/2/0) YES NO
DRD5 dopamine receptor D5 4p16.1 2(0/2/0) YES YES
TLE4 transducin-like enhancer of split 4 9q21.32 2(1/1/0) YES NO
NRG3 neuregulin 3 10q23.1 2(0/2/0) YES NO
NT5C2 5'-nucleotidase, cytosolic II 10q24.32 2(2/0/0) YES YES
NRGN neurogranin (protein kinase C substrate, RC3) 11q24 2(1/1/0) YES NO
TRIM26 tripartite motif containing 26 6p21.3 2(2/0/0) YES NO
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 17p13.3 1(0/1/0) YES YES
MCM3AP-AS1 MCM3AP antisense RNA 1 21q22.3 1(1/0/0) YES NO
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 15q13.2 1(0/1/0) YES NO
OTX2 orthodenticle homeobox 2 14q22.3 1(1/0/0) YES NO
ZNF74 zinc finger protein 74 22q11.2 1(0/1/0) YES NO
INA internexin neuronal intermediate filament protein, alpha 10q24 1(0/1/0) YES NO
CYCSP38 cytochrome c, somatic pseudogene 38 15q22.2 1(0/1/0) YES NO
NLRC5 NLR family, CARD domain containing 5 16q13 1(0/1/0) YES NO
CABIN1 calcineurin binding protein 1 22q11.23 1(0/0/1) YES NO
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 13q32.3 1(0/1/0) YES NO
LRRC36 leucine rich repeat containing 36 16q22.1 1(1/0/0) YES NO
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 8p22 1(0/1/0) YES NO
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 17q12 1(0/1/0) YES NO
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2p21 1(0/1/0) YES YES
GRID1 glutamate receptor, ionotropic, delta 1 10q22 1(0/0/1) YES NO
SNCG synuclein, gamma (breast cancer-specific protein 1) 10q23.2-q23.3 1(0/1/0) YES NO
TP53I3 tumor protein p53 inducible protein 3 2p23.3 1(1/0/0) YES NO
SEMG2 semenogelin II 20q12-q13.1 1(1/0/0) YES NO
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 3p22.1 1(0/0/1) YES NO
PI4K2B phosphatidylinositol 4-kinase type 2 beta 4p15.31 1(0/1/0) YES NO
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 11p15.1 1(0/1/0) YES NO
IL17RA interleukin 17 receptor A 22q11.1 1(0/1/0) YES NO
CAPN10 calpain 10 2q37.3 1(1/0/0) YES NO
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 14q21-q22 1(1/0/0) YES NO
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 15q13 1(1/0/0) YES NO
IFT88 intraflagellar transport 88 13q12.1 1(0/1/0) YES YES
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 18q12.3 1(1/0/0) YES NO
NEFM neurofilament, medium polypeptide 8p21 1(0/1/0) YES NO
BCL9 B-cell CLL/lymphoma 9 1q21 1(1/0/0) YES YES
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 9q31.1 1(0/1/0) YES NO
IFI44L interferon-induced protein 44-like 1p22.3 1(0/1/0) YES NO
RGMA repulsive guidance molecule family member a 15q26.1 1(1/0/0) YES YES
VRK2 vaccinia related kinase 2 2p16.1 1(0/1/0) YES NO
TXNL1 thioredoxin-like 1 18q21.31 1(0/0/1) YES YES
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 1(0/1/0) YES YES
NDE1 nudE neurodevelopment protein 1 16p13.11 1(1/0/0) YES NO
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2p15-p13 1(0/1/0) YES NO
DGCR14 DiGeorge syndrome critical region gene 14 22q11.21 1(0/1/0) YES NO
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 9q31-q32 1(1/0/0) YES NO
SYNGAP1 synaptic Ras GTPase activating protein 1 6p21.3 1(0/1/0) YES NO
PSKH1 protein serine kinase H1 16q22.1 1(1/0/0) YES NO
MED15 mediator complex subunit 15 22q11.2 1(0/1/0) YES NO
CCDC102B coiled-coil domain containing 102B 18q22.1 1(0/1/0) YES YES
ZBED4 zinc finger, BED-type containing 4 22q13.33 1(1/0/0) YES NO
UFD1L ubiquitin fusion degradation 1 like (yeast) 22q11.2 1(0/1/0) YES NO
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 1(1/0/0) YES YES
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 8p21-p11.2 1(0/1/0) YES NO
NCAPD3 non-SMC condensin II complex, subunit D3 11q25 1(1/0/0) YES NO
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 6p21 1(1/0/0) YES NO
FAM20B family with sequence similarity 20, member B 1q25.2 1(0/1/0) YES YES
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 22q13.2 1(1/0/0) YES NO
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 14q24.3 1(1/0/0) YES NO
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 6p21 1(1/0/0) YES YES
MIR137 microRNA 137 1p21.3 1(1/0/0) YES NO
PHF8 PHD finger protein 8 Xp11.22 1(0/0/1) YES NO
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 9q34.13 1(0/1/0) YES NO
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2p16.1 1(1/0/0) YES NO
ZIC2 Zic family member 2 13q32 1(0/1/0) YES NO
AS3MT arsenite methyltransferase 10q24.33 1(1/0/0) YES YES
ZSCAN31 zinc finger and SCAN domain containing 31 6p 1(1/0/0) YES NO
INTS6 integrator complex subunit 6 13q14.3 1(1/0/0) YES NO
TMEM108 transmembrane protein 108 3q22.1 1(1/0/0) YES NO
ZNF490 zinc finger protein 490 19p13.2 1(1/0/0) YES NO
MPC2 mitochondrial pyruvate carrier 2 1q24 1(0/1/0) YES NO
LGI1 leucine-rich, glioma inactivated 1 10q24 1(0/1/0) YES NO
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 22q11.2 1(1/0/0) YES YES
MMP3 matrix metallopeptidase 3 11q22.3 1(0/1/0) YES NO
GFI1B growth factor independent 1B transcription repressor 9q34.13 1(0/1/0) YES NO
PICK1 protein interacting with PRKCA 1 22q13.1 1(0/1/0) YES NO
LRR1 leucine rich repeat protein 1 14q21.3 1(1/0/0) YES NO
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 7q36.1 1(0/0/1) YES YES
MYL12B myosin, light chain 12B, regulatory 18p11.31 1(1/0/0) YES NO
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 18p11.31 1(1/0/0) YES NO
C10orf120 chromosome 10 open reading frame 120 10q26.13 1(1/0/0) YES NO
BRCA2 breast cancer 2, early onset 13q12-q13 1(1/0/0) YES NO
ROR2 receptor tyrosine kinase-like orphan receptor 2 9q22 1(0/1/0) YES NO