Gene Report

Basic Info
Approved Symbol POLE2
Symbol Alias DPE2
Approved Name polymerase (DNA directed), epsilon 2, accessory subunit
Previous Name polymerase (DNA directed), epsilon 2 (p59 subunit)
Name Alias DNA polymerase epsilon subunit B
Location 14q21-q22
Position chr14:49643555-49688422, -1
External Links HGNC: 9178
Entrez Gene: 5427
Ensembl: ENSG00000100479
UCSC: uc001wwu.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Moskvina, V.,2009 In BP:Smallest P-value per gene=0.00939, Product of P truncation <=0.01=0.00094, Product of P truncation <=0.001=NA. It showed evidence for association with BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 1)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 5)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr14:49643555..49688422 View in gBrowse
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