Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	BMP6
Previous Symbol	VGR
Symbol Alias	VGR1
Approved Name	bone morphogenetic protein 6
Previous Name	vegetal related growth factor (TGFB-related)
Location	6p24-p23
Position	chr6:7726797-7881422, 1
External Links	HGNC: 1073 Entrez Gene: 654 Ensembl: ENSG00000153162 UCSC: uc003mxu.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0059. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 43)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001958	endochondral ossification	biological process	IEA	3
GO:0005125	cytokine activity	molecular function	IBA	13
GO:0006954	inflammatory response	biological process	IEA	23

GO terms by database search (count: 40)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031988	membrane-bounded vesicle	cellular component	IEA	1
GO:0005615	extracellular space	cellular component	IBA	85
GO:0008083	growth factor activity	molecular function	IEA	15
GO:0032526	response to retinoic acid	biological process	IEA	5
GO:0001501	skeletal system development	biological process	TAS[8089189]	16
GO:0010039	response to iron ion	biological process	IEA	4
GO:0040007	growth	biological process	IEA	4
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IEA	11
GO:0032349	positive regulation of aldosterone biosynthetic process	biological process	IDA[16527843]	1
GO:0043408	regulation of MAPK cascade	biological process	IBA	6
GO:0003323	type B pancreatic cell development	biological process	IDA[11865031]	1
GO:0032026	response to magnesium ion	biological process	IEA	1
GO:0001649	osteoblast differentiation	biological process	IEA	9
GO:0050679	positive regulation of epithelial cell proliferation	biological process	IDA[11865031]	9
GO:0006955	immune response	biological process	IMP[16886151]	19
GO:2000105	positive regulation of DNA-dependent DNA replication	biological process	NAS[15516325]	1
GO:0030539	male genitalia development	biological process	IEA	2
GO:0051216	cartilage development	biological process	IEA	6
GO:0014823	response to activity	biological process	IEA	11
GO:0006879	cellular iron ion homeostasis	biological process	IEA	7
GO:0001822	kidney development	biological process	IEA	13
GO:0045669	positive regulation of osteoblast differentiation	biological process	IDA[18436533]	7
GO:2000860	positive regulation of aldosterone secretion	biological process	IEA	1
GO:0045603	positive regulation of endothelial cell differentiation	biological process	IEA	2
GO:0030509	BMP signaling pathway	biological process	IDA[18436533]	6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[16527843]; NAS[15516325]	91
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	biological process	IDA[17244894]	2
GO:0001654	eye development	biological process	IEA	2
GO:0046982	protein heterodimerization activity	molecular function	IDA[7811286]	42
GO:0030501	positive regulation of bone mineralization	biological process	IDA[18436533]	4
GO:0005160	transforming growth factor beta receptor binding	molecular function	IBA	2
GO:0051384	response to glucocorticoid	biological process	IEA	11
GO:0070700	BMP receptor binding	molecular function	IDA[7811286]	1
GO:0071260	cellular response to mechanical stimulus	biological process	IEA	12
GO:0045666	positive regulation of neuron differentiation	biological process	IEA	8
GO:0042981	regulation of apoptotic process	biological process	IBA	10
GO:0050714	positive regulation of protein secretion	biological process	NAS[15516325]	2
GO:0060395	SMAD protein signal transduction	biological process	IDA[17244894]	4
GO:0032332	positive regulation of chondrocyte differentiation	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04350	TGF-beta signaling pathway	10

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
BMP6	CHRDL2	NO	in vivo	14660436
BMP6	BMPR1B	NO	in vivo	10504300 , 11401330
BMP6	ACVR2A	NO	in vivo	10504300
BMP6	SOSTDC1	NO	in vitro	14623234
BMP6	BMPR2	NO	in vivo	11401330
BMP6	SMAD5	NO	in vivo	10504300
BMP6	BMPR1A	NO	in vivo	10504300 , 11401330
BMP6	BMPER	NO	in vivo	12897139
BMP6	NCOA3	NO	in vivo	10504300

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p24	chr6:7100000-13400000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
19694819	800	Positive

Gene relationship with MDD

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Region: chr6:7726797..7881422 View in gBrowse