Gene Report

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Basic Info

Approved Symbol	AANAT
Symbol Alias	SNAT
Approved Name	aralkylamine N-acetyltransferase
Previous Name	arylalkylamine N-acetyltransferase
Name Alias	serotonin N-acetyltransferase
Location	17q25.1
Position	chr17:76453351-76470117, 1
External Links	HGNC: 19 Entrez Gene: 15 Ensembl: ENSG00000129673 UCSC: uc002jro.3
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Mansour, H. A.,2009		Gene-based tests:X<sup>2</sup>=1.997, P-value = 0.482 in additive model, X<sup>2</sup>=1.811, P-value = 0.538 in dominant model, X<sup>2</sup>=1.818, P-value = 0.55 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI.	Negative	Comment on Study
Byrne, E. M., 2014		P-value=0.71. Gene-based tests show no significant association between this gene and BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS	5
GO:0051412	response to corticosterone	biological process	IEA	9
GO:0071320	cellular response to cAMP	biological process	IDA[11313340]	8
GO:0007623	circadian rhythm	biological process	IMP[12736803]; NAS[8661026]	40
GO:0071889	14-3-3 protein binding	molecular function	IEA	7
GO:0004059	aralkylamine N-acetyltransferase activity	molecular function	IDA[11313340]; NAS[8661026]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0034695	response to prostaglandin E	biological process	IEA	1
GO:0006474	N-terminal protein amino acid acetylation	biological process	IDA[11313340]	1
GO:0010043	response to zinc ion	biological process	IEA	5
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11313340]	50
GO:0034097	response to cytokine	biological process	IEA	4
GO:0009416	response to light stimulus	biological process	IEA	5
GO:0051592	response to calcium ion	biological process	IEA	7
GO:0004060	arylamine N-acetyltransferase activity	molecular function	IEA	2
GO:0032868	response to insulin	biological process	IEA	10
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0030187	melatonin biosynthetic process	biological process	IDA[11313340]; IEA; NAS[8661026]	2
GO:0046688	response to copper ion	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00380	Tryptophan metabolism	9

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AANAT	YWHAZ	NO	in vitro;in vivo	11336675 , 11427721
AANAT	F2	NO	in vitro	11427721
AANAT	PRKACA	NO	in vitro	11336675

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17q25	chr17:72900000-83257441	1 (0/0/1)
17q11-25	chr17:25100000-83257441	1 (1/0/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19839995	Gene-based tests:X<sup>2</sup>=3.101, P-value = 0.268 in additive model in SZ/SZA, X<sup>2</sup>=2.817, P-value = 0.34 in dominant model in SZ/SZA, X<sup>2</sup>=2.747, P-value = 0.345 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
24687905	P-value=0.17. The results from the gene-based test indicate that AANAT is the best candidates among the circadian genes to influence SCZ risk.	Negative

Reference	ID in SZGene	Result Category
19839995	875	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
24687905	P-value=0.24. Gene-based tests show no significant association between this gene and MDD.	Negative

Reference	Description	Category in MDD	Link in MK4MDD
20459461	Common variants (MAF > 2%) were included in a case-control association analysis that showed significant association after multiple testing correction of two SNPs located in the promoter region of AANAT with MD: rs3760138 (P = 0.00006) and rs4238989 (P = 0.005)	Pos	AANAT

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Region: chr17:76453351..76470117 View in gBrowse