Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	NQO1
Previous Symbol	NMOR1, DIA4
Symbol Alias	DHQU, QR1, DTD
Approved Name	NAD(P)H dehydrogenase, quinone 1
Previous Name	diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
Location	16q12-q22
Position	chr16:69706996-69726951, -1
External Links	HGNC: 2874 Entrez Gene: 1728 Ensembl: ENSG00000181019 UCSC: uc002exp.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pae, C. U., 2007 (b)	Other variant: NQO1_C609T	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0007568	aging	biological process	IEA	22
GO:0032355	response to estradiol	biological process	IEA	11
GO:0007584	response to nutrient	biological process	IEA	10
GO:0007271	synaptic transmission, cholinergic	biological process	TAS[9579781]	14
GO:0006809	nitric oxide biosynthetic process	biological process	TAS[9579781]	8
GO:0042802	identical protein binding	molecular function	IPI[25143260]	44
GO:0045471	response to ethanol	biological process	IEA	24
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0009636	response to toxic substance	biological process	TAS[10393963]	12
GO:0005829	cytosol	cellular component	TAS	223
GO:0006805	xenobiotic metabolic process	biological process	TAS[10393963]	19
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	11
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0019430	removal of superoxide radicals	biological process	IEA	2
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	3
GO:0043086	negative regulation of catalytic activity	biological process	IEA	5
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	molecular function	IEA	1
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	molecular function	TAS[9579781]	1
GO:0005515	protein binding	molecular function	IPI[18388957]	563
GO:0004784	superoxide dismutase activity	molecular function	IEA	2

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00100	Biosynthesis of steroids	1

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
p53hypoxiaPathway	Hypoxia and p53 in the Cardiovascular system	6

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NQO1	DNAJB1	NO	in vitro;in vivo	11821413
NQO1	TP53	NO	in vivo	12529318
NQO1	ING1	NO	in vivo	18388957

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
NQO1_C609T	point mutation		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16q22	chr16:66600000-74100000	1 (0/1/0)
16q12.2-23.1	chr16:52600000-79200000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
12834817	151	Negative
15151706	151	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
17644186	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr16:69706996..69726951 View in gBrowse