Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NQO1
Previous Symbol	NMOR1, DIA4
Symbol Alias	DHQU, QR1, DTD
Approved Name	NAD(P)H dehydrogenase, quinone 1
Previous Name	diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
Location	16q12-q22
Position	chr16:69706996-69726951, -1
External Links	HGNC: 2874 Entrez Gene: 1728 Ensembl: ENSG00000181019 UCSC: uc002exp.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Pae, C. U., 2007 (b)	Other variant: NQO1_C609T	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0007568	aging	biological process	IEA	22
GO:0032355	response to estradiol	biological process	IEA	11
GO:0007584	response to nutrient	biological process	IEA	10
GO:0007271	synaptic transmission, cholinergic	biological process	TAS[9579781]	14
GO:0006809	nitric oxide biosynthetic process	biological process	TAS[9579781]	8
GO:0042802	identical protein binding	molecular function	IPI[25143260]	44
GO:0045471	response to ethanol	biological process	IEA	24
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0009636	response to toxic substance	biological process	TAS[10393963]	12
GO:0005829	cytosol	cellular component	TAS	223
GO:0006805	xenobiotic metabolic process	biological process	TAS[10393963]	19
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	11
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0019430	removal of superoxide radicals	biological process	IEA	2
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	20
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	3
GO:0043086	negative regulation of catalytic activity	biological process	IEA	5
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	molecular function	IEA	1
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	molecular function	TAS[9579781]	1
GO:0005515	protein binding	molecular function	IPI[18388957]	563
GO:0004784	superoxide dismutase activity	molecular function	IEA	2

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00100	Biosynthesis of steroids	1

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
p53hypoxiaPathway	Hypoxia and p53 in the Cardiovascular system	6

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NQO1	ING1	NO	in vivo	18388957
NQO1	TP53	NO	in vivo	12529318
NQO1	DNAJB1	NO	in vitro;in vivo	11821413

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
NQO1_C609T	point mutation		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16q22	chr16:66600000-74100000	1 (0/1/0)
16q12.2-23.1	chr16:52600000-79200000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
12834817	151	Negative
15151706	151	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
17644186	The NQO1 gene polymorphism was not related to a susceptibility to mood disorders (BD and MDD).	Negative

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr16:69706996..69726951 View in gBrowse