Gene Report

Basic Info
Approved Symbol SYNJ1
Symbol Alias INPP5G
Approved Name synaptojanin 1
Location 21q22.2
Position chr21:32628759-32728048, -1
External Links HGNC: 11503
Entrez Gene: 8867
Ensembl: ENSG00000159082
UCSC: uc002yqh.2
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Stopkova, P., 2004 (b) Other variant: SYNJ1_intron12_IVS12+15delT,+17delT In conclusion, although we did not replicate the original finding, the role of SYNJ1 in the pathogenesis of bipolar disorder cannot be ruled out and further investigation is warranted. Negative Comment on Study
Saito, T.,2001 Other variant: SYNJ1_IVS12+15delT,+17delT, SYNJ1_IVS28-7G/T, SYNJ1_IVS29+14C/T, SYNJ1_K295R We failed to unequivocally identify a specific SYNJ1 allele that could be responsible for putative chromosome 21q22-linked BPD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 22)

GO terms by PBA (count: 0)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr21:32628759..32728048 View in gBrowse
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