Gene Report

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Basic Info

Approved Symbol	ARHGAP18
Symbol Alias	MacGAP, bA307O14.2
Approved Name	Rho GTPase activating protein 18
Location	6q23.1
Position	chr6:129576132-129710225, -1
External Links	HGNC: 21035 Entrez Gene: 93663 Ensembl: ENSG00000146376 UCSC: uc003qbr.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0010. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005096	GTPase activator activity	molecular function	IEA	19
GO:0005829	cytosol	cellular component	TAS	223
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ARHGAP18	MPP6	NO	yeast 2-hybrid	15231747
ARHGAP18	MPHOSPH6	NO	yeast 2-hybrid	15231747

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
19065146	927	Positive

Gene relationship with MDD

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Region: chr6:129576132..129710225 View in gBrowse