Gene Report

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Basic Info

Approved Symbol	PFN4
Approved Name	profilin family, member 4
Location	2p24.1
Position	chr2:24115371-24123477, -1
External Links	HGNC: 31103 Entrez Gene: 375189 Ensembl: ENSG00000176732 UCSC: uc002rfa.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.00744, Product of P truncation <=0.01=0.00744, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005856	cytoskeleton	cellular component	IEA	30
GO:0008289	lipid binding	molecular function	IEA	8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00045, Product of P truncation <=0.01=0.00045, Product of P truncation <=0.001=0.00045 It showed evidence for association with SZ.	Positive

Gene relationship with MDD

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Region: chr2:24115371..24123477 View in gBrowse