Gene Report

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Basic Info

Approved Symbol	QKI
Symbol Alias	QK3
Approved Name	QKI, KH domain containing, RNA binding
Previous Name	quaking homolog, KH domain RNA binding (mouse)
Location	6q26
Position	chr6:163414000-163578596, 1
External Links	HGNC: 21100 Entrez Gene: 9444 Ensembl: ENSG00000112531 UCSC: uc003qui.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs9458854	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008380	RNA splicing	biological process	IEA	8
GO:0005634	nucleus	cellular component	IEA	283
GO:0042552	myelination	biological process	IEA	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006417	regulation of translation	biological process	IEA	5
GO:0007286	spermatid development	biological process	IEA	2
GO:0010628	positive regulation of gene expression	biological process	IEA	23
GO:0061158	3'-UTR-mediated mRNA destabilization	biological process	IEA	1
GO:0001570	vasculogenesis	biological process	IEA	4
GO:0005515	protein binding	molecular function	IPI[16189514]	563
GO:0017124	SH3 domain binding	molecular function	IEA	11
GO:0051028	mRNA transport	biological process	IEA	1
GO:0003729	mRNA binding	molecular function	IEA	5
GO:0042692	muscle cell differentiation	biological process	IEA	5
GO:0006397	mRNA processing	biological process	IEA	8
GO:0042759	long-chain fatty acid biosynthetic process	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0044822	poly(A) RNA binding	molecular function	IDA[22681889]	44

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 19)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
QKI	USH1C	NO	yeast 2-hybrid	16713569
QKI	PTBP1	NO	yeast 2-hybrid	16713569
QKI	PCBP1	NO	yeast 2-hybrid	16713569
QKI	RBM9	NO	yeast 2-hybrid	16713569
QKI	HCLS1	NO	yeast 2-hybrid	16713569
QKI	C10orf10	NO	yeast 2-hybrid	16713569
QKI	PCBP4	NO	yeast 2-hybrid	16713569
QKI	FUBP3	NO	yeast 2-hybrid	16713569
QKI	THAP1	NO	yeast 2-hybrid	16713569
QKI	PCBP2	NO	yeast 2-hybrid	16713569
QKI	PTBP2	YES	yeast 2-hybrid	16713569
QKI	RBM14	NO	yeast 2-hybrid	16713569
QKI	PRMT1	NO	in vitro;in vivo	12529443
QKI	HNRNPK	NO	yeast 2-hybrid	16189514 , 16713569
QKI	PSMF1	YES	yeast 2-hybrid	16713569
QKI	DAZ4	NO	yeast 2-hybrid	12511597
QKI	RNF138	NO	yeast 2-hybrid	16713569
QKI	SERF2	NO	yeast 2-hybrid	16713569
QKI	RBPMS	NO	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9458854	chr6:163547549 - 163547549(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs9458846	chr6:163517299 - 163517299(1)	intron_variant; NMD_transcript_variant
rs9458853	chr6:163541635 - 163541635(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs9458855	chr6:163547640 - 163547640(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs12525340	chr6:163553419 - 163553419(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs9458841	chr6:163513113 - 163513113(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q26	chr6:160600000-164100000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17893707	596	Negative
18938205	596	Negative

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
17938633	Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t)	Pos	QKI

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Region: chr6:163414000..163578596 View in gBrowse