Gene Report

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Basic Info

Approved Symbol	GSTT1
Approved Name	glutathione S-transferase theta 1
Location	22q11.23 alternate reference locus
Position	chr22:270314-278459, -1
External Links	HGNC: 4641 Entrez Gene: 2952 Ensembl: ENSG00000277656 UCSC: uc002zze.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Mohammadynejad, P.,2011	Haplotype: (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_null)-(GSTT1_null)), (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_null)-(GSTT1_positive)), (GSTM1_positive/null) - (GSTT1_positive/null)((GSTM1_positive)-(GSTT1_null)) Other variant: GSTT1_positive/null	The present finding indicated that GSTM1 and GSTT1 are candidate polymorphisms for susceptibility to BDP among adolescents.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006749	glutathione metabolic process	biological process	IDA[20097269]	5
GO:0004364	glutathione transferase activity	molecular function	IDA[20097269]	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005829	cytosol	cellular component	IDA[8799324]; TAS	223
GO:0055114	oxidation-reduction process	biological process	IDA[9307035]	43
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0004602	glutathione peroxidase activity	molecular function	IDA[9307035]	4
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS	6

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00982	Drug metabolism - cytochrome P450	6
hsa00980	Metabolism of xenobiotics by cytochrome P450	3

ID	Name	No. of Genes in BDgene	Brief Description
hsa00480	Glutathione metabolism	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
GSTT1_positive/null	insertion/deletion		1 (0/1/0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
17586054	528	Positive
18449862	528	Negative

Gene relationship with MDD

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Region: chr22:270314..278459 View in gBrowse