Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	IL6
Previous Symbol	IFNB2
Symbol Alias	IL-6, BSF2, HGF, HSF
Approved Name	interleukin 6
Previous Name	interleukin 6 (interferon, beta 2)
Name Alias	interferon, beta 2
Location	7p21-p15
Position	chr7:22725884-22732002, 1
External Links	HGNC: 6018 Entrez Gene: 3569 Ensembl: ENSG00000136244 UCSC: uc003svj.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Clerici, M.,2009	Other variant: IL6_174G/C	The distribution of cytokines interleukin (IL)-6 polymorphism was not significantly different in the BD group.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 102)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031175	neuron projection development	biological process	IMP[3264880]	10
GO:0005125	cytokine activity	molecular function	IDA[3023045]; NAS[10443688]	13
GO:0006954	inflammatory response	biological process	IDA[10443688]	23
GO:0045765	regulation of angiogenesis	biological process	IC[8557680]	4

GO terms by database search (count: 98)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032722	positive regulation of chemokine production	biological process	IDA[10510402]; NAS[16034137]	4
GO:0050710	negative regulation of cytokine secretion	biological process	IEA	2
GO:0050830	defense response to Gram-positive bacterium	biological process	TAS[16034137]	7
GO:0033160	positive regulation of protein import into nucleus, translocation	biological process	IEA	2
GO:0050829	defense response to Gram-negative bacterium	biological process	TAS[16034137]	3
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	biological process	IEA	3
GO:0051602	response to electrical stimulus	biological process	IEA	11
GO:0008284	positive regulation of cell proliferation	biological process	IDA[2261637]; IMP[18719127]	44
GO:0045666	positive regulation of neuron differentiation	biological process	IEA	8
GO:0043200	response to amino acid	biological process	IEA	6
GO:0046888	negative regulation of hormone secretion	biological process	IEA	1
GO:0070301	cellular response to hydrogen peroxide	biological process	IDA[19168699]	4
GO:0042102	positive regulation of T cell proliferation	biological process	IDA[3130269]	6
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0005896	interleukin-6 receptor complex	cellular component	IDA[12829785]	1
GO:0071356	cellular response to tumor necrosis factor	biological process	IEA	7
GO:0002690	positive regulation of leukocyte chemotaxis	biological process	TAS[16034137]	1
GO:0009408	response to heat	biological process	IEA	12
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[7749983]	11
GO:0060445	branching involved in salivary gland morphogenesis	biological process	IEA	3
GO:0046849	bone remodeling	biological process	IEA	2
GO:0051897	positive regulation of protein kinase B signaling	biological process	IEA	11
GO:2000366	positive regulation of STAT protein import into nucleus	biological process	IC[17324931]	2
GO:0030168	platelet activation	biological process	TAS[7831669]	22
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	14
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IDA[7508917]	12
GO:0051024	positive regulation of immunoglobulin secretion	biological process	IDA[3491322]	3
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0001781	neutrophil apoptotic process	biological process	IDA[7595060]	3
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IEA	13
GO:0072540	T-helper 17 cell lineage commitment	biological process	ISS	1
GO:0008360	regulation of cell shape	biological process	IEA	16
GO:0045599	negative regulation of fat cell differentiation	biological process	NAS[16464856]	7
GO:0016049	cell growth	biological process	IEA	7
GO:0019221	cytokine-mediated signaling pathway	biological process	IDA[12643274]	23
GO:0010888	negative regulation of lipid storage	biological process	NAS[16464856]	2
GO:0042593	glucose homeostasis	biological process	IEA	19
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IDA[10510402]	11
GO:0002675	positive regulation of acute inflammatory response	biological process	IDA[2444978]	2
GO:0032966	negative regulation of collagen biosynthetic process	biological process	IDA[12419823]	2
GO:0031667	response to nutrient levels	biological process	IEA	7
GO:2000676	positive regulation of type B pancreatic cell apoptotic process	biological process	TAS[18719127]	2
GO:0010574	regulation of vascular endothelial growth factor production	biological process	IDA[8557680]	2
GO:1901215	negative regulation of neuron death	biological process	IEA	6
GO:0070091	glucagon secretion	biological process	ISS[18719127]	1
GO:0046427	positive regulation of JAK-STAT cascade	biological process	IDA[12419823]	3
GO:0006469	negative regulation of protein kinase activity	biological process	IEA	7
GO:0051384	response to glucocorticoid	biological process	IDA[10443688]	11
GO:0045630	positive regulation of T-helper 2 cell differentiation	biological process	IEA	2
GO:0005138	interleukin-6 receptor binding	molecular function	IPI[12829785]; IPI[12829785]; NAS[1883960]	1
GO:0046716	muscle cell cellular homeostasis	biological process	IEA	4
GO:0007568	aging	biological process	IEA	22
GO:0045669	positive regulation of osteoblast differentiation	biological process	TAS[12372336]	7
GO:0002384	hepatic immune response	biological process	IDA[2444978]; TAS[12832423]	1
GO:0045740	positive regulation of DNA replication	biological process	IEA	7
GO:0071222	cellular response to lipopolysaccharide	biological process	IMP[23776175]	12
GO:0042493	response to drug	biological process	IEA	57
GO:0050679	positive regulation of epithelial cell proliferation	biological process	IEA	9
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IDA[12419823]	12
GO:0032868	response to insulin	biological process	IEA	10
GO:0031000	response to caffeine	biological process	IEA	3
GO:0008083	growth factor activity	molecular function	IDA[12643274]	15
GO:0032494	response to peptidoglycan	biological process	NAS[16034137]	1
GO:0045454	cell redox homeostasis	biological process	IEA	4
GO:0045727	positive regulation of translation	biological process	IDA[16732314]	4
GO:0070102	interleukin-6-mediated signaling pathway	biological process	IDA[12552091]	1
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	5
GO:0005515	protein binding	molecular function	IPI[11238858]	563
GO:0006959	humoral immune response	biological process	IC[3491322]	5
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[7749983]	58
GO:0002446	neutrophil mediated immunity	biological process	TAS[16034137]	4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[17324931]	91
GO:0051971	positive regulation of transmission of nerve impulse	biological process	IEA	3
GO:0045721	negative regulation of gluconeogenesis	biological process	IEA	4
GO:0005576	extracellular region	cellular component	TAS	97
GO:0071549	cellular response to dexamethasone stimulus	biological process	IEA	4
GO:0071347	cellular response to interleukin-1	biological process	IEA	3
GO:0006953	acute-phase response	biological process	TAS[12832423]	3
GO:0051607	defense response to virus	biological process	IDA[3023045]	6
GO:0032755	positive regulation of interleukin-6 production	biological process	IDA[10510402]	8
GO:0010996	response to auditory stimulus	biological process	IEA	4
GO:0050871	positive regulation of B cell activation	biological process	IDA[3491322]	1
GO:0002548	monocyte chemotaxis	biological process	IC[10510402]	3
GO:0043066	negative regulation of apoptotic process	biological process	IDA[7595060]	46
GO:0005615	extracellular space	cellular component	IDA[10443688]	85
GO:0042832	defense response to protozoan	biological process	IEA	3
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	biological process	IEA	2
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0048635	negative regulation of muscle organ development	biological process	IEA	1
GO:0046677	response to antibiotic	biological process	IEA	4
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological process	IDA[7508917]	10
GO:0045079	negative regulation of chemokine biosynthetic process	biological process	ISS	1
GO:0043065	positive regulation of apoptotic process	biological process	IDA[9949178]	25
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[12419823]	13
GO:0031018	endocrine pancreas development	biological process	ISS[18719127]	6
GO:0051592	response to calcium ion	biological process	IEA	7
GO:0009409	response to cold	biological process	IEA	7
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	biological process	IDA[12643274]	2

Gene related KEGG pathways (count: 6)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 6)

ID	Name	No. of Genes in BDgene
hsa05332	Graft-versus-host disease	7
hsa04060	Cytokine-cytokine receptor interaction	17
hsa04630	Jak-STAT signaling pathway	14
hsa04640	Hematopoietic cell lineage	5
hsa05060	Prion disease	7
hsa04620	Toll-like receptor signaling pathway	10

Gene related BioCarta pathways (count: 12)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 12)

ID	Name	No. of Genes in BDgene
il1rPathway	Signal transduction through IL1R	5
erythPathway	Erythrocyte Differentiation Pathway	2
LairPathway	Cells and Molecules involved in local acute inflammatory response	2
LDLpathway	Low-density lipoprotein (LDL) pathway during atherogenesis	2
il10Pathway	IL-10 Anti-inflammatory Signaling Pathway	4
cytokinePathway	Cytokine Network	4
her2Pathway	Role of ERBB2 in Signal Transduction and Oncology	7
il17Pathway	IL 17 Signaling Pathway	1
inflamPathway	Cytokines and Inflammatory Response	4
il6Pathway	IL 6 signaling pathway	3
il5Pathway	IL 5 Signaling Pathway	2
stemPathway	Regulation of hematopoiesis by cytokines	1

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
IL6	IL6R	NO	in vitro;in vivo	14557255 , 12829785
IL6	SH3GL2	NO	yeast 2-hybrid	16169070
IL6	ZBTB16	NO	yeast 2-hybrid	16169070
IL6	PTHLH	NO	in vitro	12000745
IL6	IL6ST	NO	in vivo	14557255

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
IL6_174G/C	point mutation		1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
20393813	870	Positive
19914334	870	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
19890236	The genotype distribution was significantly different between MDD and control (P< .001)	Positive

Overlap with MDD from candidate gene intersection analysis (count: 2)

Reference	Description	Category in MDD	Link in MK4MDD
16244501	No significant differences were demonstrated for the genotype or allele frequency of the IL-6 polymorphism when comparing the MDD and control groups	Neg	IL6
24424390	Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls	Pos	IL6

View in gBrowse

Region: chr7:22725884..22732002 View in gBrowse