Gene Report

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Basic Info

Approved Symbol	LRR1
Previous Symbol	PPIL5
Symbol Alias	MGC20689, LRR-1
Approved Name	leucine rich repeat protein 1
Previous Name	peptidylprolyl isomerase (cyclophilin)-like 5
Name Alias	LRR-repeat protein 1
Location	14q21.3
Position	chr14:49598697-49614672, 1
External Links	HGNC: 19742 Entrez Gene: 122769 Ensembl: ENSG00000165501 UCSC: uc001wwn.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00341, Product of P truncation <=0.01=0.0005, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016567	protein ubiquitination	biological process	IEA	18
GO:0005515	protein binding	molecular function	IPI[25416956]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q21	chr14:37400000-50400000	3 (2/0/1)
14q13.2-21.3	chr14:34800000-50400000	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q12-q22.3	chr14:24100000-57600000	1 (1/0/0)
14q13.1-q24.1	chr14:32900000-69800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr14:49598697..49614672 View in gBrowse