Gene Report

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Basic Info

Approved Symbol	MYOZ1
Previous Symbol	MYOZ
Symbol Alias	FATZ, CS-2
Approved Name	myozenin 1
Previous Name	myozenin
Name Alias	calsarcin-2
Location	10q22.1
Position	chr10:73631654-73641757, -1
External Links	HGNC: 13752 Entrez Gene: 58529 Ensembl: ENSG00000177791 UCSC: uc001jur.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		1 SNP typed, Median D'=â€¦, Median r<sup>2</sup> =â€¦, â€¦ LD blocks, â€¦ block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0015629	actin cytoskeleton	cellular component	IEA	18
GO:0030239	myofibril assembly	biological process	TAS[11114196]	2
GO:0005515	protein binding	molecular function	IPI[10427098]	563
GO:0031143	pseudopodium	cellular component	IEA	2
GO:0051373	FATZ binding	molecular function	IDA[10984498]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MYOZ1	LDB3	NO	in vivo;yeast 2-hybrid	11842093
MYOZ1	ACTN1	NO	in vivo	11842093
MYOZ1	TCAP	YES	in vitro	10984498
MYOZ1	ACTN2	NO	in vitro;in vivo	10984498
MYOZ1	PNKP	NO	yeast 2-hybrid	16189514
MYOZ1	ACTN4	NO	yeast 2-hybrid	16189514
MYOZ1	FLNC	NO	in vitro;in vivo;yeast 2-hybrid	10984498 , 11171996
MYOZ1	MAGEA11	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7080456		chr10:73631459 - 73631459(1)	downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs7080436		chr10:73631420 - 73631420(1)	downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q22	chr10:68800000-80300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	178	Negative

Gene relationship with MDD

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Region: chr10:73631654..73641757 View in gBrowse