Gene Report

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Basic Info

Approved Symbol	WWC1
Symbol Alias	KIBRA, KIAA0869, PPP1R168
Approved Name	WW and C2 domain containing 1
Previous Name	WW, C2 and coiled-coil domain containing 1
Name Alias	protein phosphatase 1, regulatory subunit 168
Location	5q34
Position	chr5:168291651-168472303, 1
External Links	HGNC: 29435 Entrez Gene: 23286 Ensembl: ENSG00000113645 UCSC: uc011den.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: WWC1_Chr5:167896045_G/A	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[16684779]	283
GO:0030674	protein binding, bridging	molecular function	IEA	8

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030010	establishment of cell polarity	biological process	TAS[24682284]	4
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[18596123]	50
GO:0032947	protein complex scaffold	molecular function	IDA[24682284]	5
GO:0005829	cytosol	cellular component	IDA[24682284]; TAS	223
GO:0043234	protein complex	cellular component	IEA	27
GO:0005515	protein binding	molecular function	IPI[16684779]	563
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[24682284]	62
GO:0035330	regulation of hippo signaling	biological process	IMP[20159598]	1
GO:0035329	hippo signaling	biological process	TAS	4
GO:0005737	cytoplasm	cellular component	IDA[16684779]	322
GO:0035331	negative regulation of hippo signaling	biological process	IDA[24682284]	1
GO:0016477	cell migration	biological process	IDA[18596123]	17
GO:0032386	regulation of intracellular transport	biological process	TAS[24682284]	1
GO:0046621	negative regulation of organ growth	biological process	IMP[24682284]	3
GO:0003713	transcription coactivator activity	molecular function	IDA[16684779]	22
GO:0032587	ruffle membrane	cellular component	IDA[18190796]	4
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[18190796]	13
GO:0019900	kinase binding	molecular function	IPI[24682284]	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
WWC1	C9orf25	NO	yeast 2-hybrid	16169070
WWC1	DDN	NO	yeast 2-hybrid	12559952
WWC1	C1orf103	NO	yeast 2-hybrid	16169070
WWC1	CDC73	NO	yeast 2-hybrid	16169070
WWC1	AIFM1	NO	yeast 2-hybrid	16169070
WWC1	KIAA0513	NO	in vivo;yeast 2-hybrid	17010949

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
WWC1_Chr5:167896045_G/A	others	Chr5:167896045	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
20185150	981	Positive

Gene relationship with MDD

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Region: chr5:168291651..168472303 View in gBrowse