Gene Report

Basic Info
Approved Symbol GCLM
Previous Symbol GLCLR
Approved Name glutamate-cysteine ligase, modifier subunit
Name Alias gamma-glutamylcysteine synthetase
Location 1p21
Position chr1:93885205-93909456, -1
External Links HGNC: 4312
Entrez Gene: 2730
Ensembl: ENSG00000023909
UCSC: uc001dqg.1
No. of Studies 1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fullerton, J. M.,2010 SNP: rs2301022, rs3170633
Haplotype: rs3170633 - rs2301022(C-T)
The allele frequency differences in the two control groups suggest that further analysis of this gene is required in psychiatrically assessed cohorts to determine the possible involvement of GCLM as a risk gene for bipolar disorder. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 0)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

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Region: chr1:93885205..93909456 View in gBrowse
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