Reference |
Tested Markers |
Statistical Values/Author Comments |
Result Category |
Comment on Study |
Tan, E. C., 2004 |
Other variant: MTHFR_C677T |
There was no significant difference in genotype distributions or allele frequencies of the MTHFR 667C>T polymorphism between controls and any of the diagnostic groups. |
Negative
|
Comment on Study |
Kunugi, H., 1998 |
Other variant: MTHFR_C677T |
Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample. |
Negative
|
Comment on Study |
Gilbody, S., 2007 |
Other variant: MTHFR_C677T |
For bipolar disorder and MTHFR C677T, the fixed-effects odds ratio for TT versus CC was 1.82 (95% CI: 1.22, 2.70), with low heterogeneity (I<sup>2</sup>= 42%)—based on 550 cases and 1, 098 controls. .
These results were robust to various sensitively analyses. This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention. |
Positive
|
Comment on Study |
El-Hadidy, M. A., 2013 |
Other variant: MTHFR_C677T |
The present findings suggest that the MTHFR C677T polymorphism is likely associated with the risk of developing BD and schizophrenia, and influences the age at onset of schizophrenia but not the age at onset of BD. |
Positive
|
Comment on Study |
Arinami, T.,1997 |
Other variant: MTHFR_C677T |
No significant differences were found in bipolar groups for MTHFR gene. |
Negative
|
Comment on Study |
Kempisty, B., 2007 (a) |
Other variant: MTHFR_A1298C |
The results confirm association of BD with the 1p36.3 MTHFR locus and with the methyl group transfer using folatedependent one-carbon pathway. |
Positive
|
Comment on Study |
Kempisty, B., 2006 |
Other variant: MTHFR_C677T |
The data may suggest the association of homozygous 677TT genotype of MTHFR gene with bipolar disorder and schizophrenia. |
Positive
|
Comment on Study |
Zintzaras, E., 2006 |
Other variant: MTHFR_C677T |
The meta-analysis results suggested that east Asians have a greater genetic risk from the MTHFR gene in developing schizophrenia and depression, and that the genetic effects in bipolar disorder and depression are different. A further exploration of the involvement of the MTHFR gene in the susceptibility to schizophrenia and affective disorders, with a greater number of studies with larger sample sizes, however, are needed to fully establish the role of the MTHFR gene. |
Positive
|
Comment on Study |
Reif, A.,2005 |
Other variant: MTHFR_C677T, MTHFR_A1298C |
The 1298C variant was significantly associated with both Bip and MD arguing that variation in the MTHFR gene contributes to the genetic risk for affective psychoses. |
Positive
|
Comment on Study |
Peerbooms, O. L.,2011 |
Other variant: MTHFR_A1298C |
There was evidence for diagnostic moderation indicating a significant association with BPD |
Positive
|
Comment on Study |
Rai, V.,2011 |
Other variant: MTHFR_C677T |
It shows meager association between MTHFR C677T genotype and bipolar disorder. |
Positive
|
Comment on Study |
Cohen-Woods, S.,2010 |
Other variant: MTHFR_C677T |
Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. |
Negative
|
Comment on Study |
Yosifova, A.,2009 |
SNP: rs1801133 |
No SNP of this gene had significant association with BD in our population. |
Negative
|
Comment on Study |
Chen, Z.,2009 |
Other variant: MTHFR_C677T |
In conclusion, pooled analysis of data from seven studies indicates MTHFR C677T is not significantly associated with bipolar disorder. Genome wide association studies also did not find any clues between markers of MTHFR gene and bipolar. Although MTHFR C677T is associated with schizophrenia by other metaanalysis, our data suggest no evidence for a major role of this polymorphism in the pathogenesis of bipolar disorder. The results implied different genetic background of schizophrenia and bipolar disorder to some extent. |
Negative
|
Comment on Study |
Wang, L. J., 2015 |
Other variant: MTHFR_C677T |
Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype for the protective effect on the odds of developing BP-II. |
Positive
|
Comment on Study |
Hu C.Y., 2014 |
Other variant: MTHFR_exon 4_C677T, MTHFR_exon 7_A1298C |
We conclude that MTHFR polymorphism is associated with BPD among Asian, African populations, but not the white. |
Positive
|
Comment on Study |