Gene Report

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Basic Info

Approved Symbol	TP53I3
Symbol Alias	PIG3
Approved Name	tumor protein p53 inducible protein 3
Location	2p23.3
Position	chr2:24077433-24085861, -1
External Links	HGNC: 19373 Entrez Gene: 9540 Ensembl: ENSG00000115129 UCSC: uc002rez.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.0087, Product of P truncation <=0.01=0.0087, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0048038	quinone binding	molecular function	IDA[19349281]	2
GO:0042803	protein homodimerization activity	molecular function	IPI[19349281]	71
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0070402	NADPH binding	molecular function	IDA[19349281]	3
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0003960	NADPH:quinone reductase activity	molecular function	IDA[19349281]	1
GO:0006739	NADP metabolic process	biological process	IDA[19349281]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04115	p53 signaling pathway	4

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TP53I3	UNC119	NO	yeast 2-hybrid	16169070
TP53I3	UBR1	NO	yeast 2-hybrid	16169070
TP53I3	FUNDC2	NO	yeast 2-hybrid	16169070
TP53I3	EEF1G	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 2	chr2:0-242193529	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00028, Product of P truncation <=0.01=0.00028, Product of P truncation <=0.001=0.00028 It showed evidence for association with SZ.	Positive

Gene relationship with MDD

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Region: chr2:24077433..24085861 View in gBrowse