Gene Report

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Basic Info

Approved Symbol	C15orf53
Symbol Alias	FLJ35695
Approved Name	chromosome 15 open reading frame 53
Location	15q14
Position	chr15:38696598-38700038, 1
External Links	HGNC: 33796 Entrez Gene: 400359 Ensembl: ENSG00000175779 UCSC: uc001zkf.1
No. of Studies	3 (Positive: 0; Negative: 1; trend: 2)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs12912251	BD ImmunoChip:P-value = 0.029,OR = 1.125;ImmunoChip, PGC-BD combined data:P-balue = 0.000000294,OR = 1.103 Suggestive association was found.	Trend	Comment on Study
Kranz, T. M.,2012	Haplotype: rs7171233 - rs7165988 - rs2172835(T-C-C), rs7171233 - rs7165988 - rs2172835(A-G-T)	Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples.	Negative	Comment on Study
Sklar, P.,2011	SNP: rs12912251	Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 0)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 12)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12899449	chr15:38703290 - 38703290(1)	downstream_gene_variant	1(1/0/0)
rs2172835	chr15:38697970 - 38697970(1)	intron_variant	1(0/0/1)
rs12912251	chr15:38694167 - 38694167(1)	downstream_gene_variant; upstream_gene_variant	2(0/0/2)

rs_ID	Location	Functional Annotation
rs7183893	chr15:38704780 - 38704780(1)	downstream_gene_variant
rs7171233	chr15:38696559 - 38696559(1)	upstream_gene_variant
rs7163869	chr15:38696190 - 38696190(1)	upstream_gene_variant
rs12903120	chr15:38695896 - 38695896(1)	upstream_gene_variant
rs12898460	chr15:38694612 - 38694612(1)	upstream_gene_variant
rs12901215	chr15:38700692 - 38700692(1)	downstream_gene_variant
rs2132157	chr15:38700346 - 38700346(1)	downstream_gene_variant
rs12916379	chr15:38699319 - 38699319(1)	3_prime_UTR_variant
rs7165988	chr15:38696614 - 38696614(1)	missense_variant; synonymous_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22944046	Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples.	Negative

Gene relationship with MDD

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Region: chr15:38696598..38700038 View in gBrowse