Gene Report

Basic Info
Approved Symbol C15orf53
Symbol Alias FLJ35695
Approved Name chromosome 15 open reading frame 53
Location 15q14
Position chr15:38696598-38700038, 1
External Links HGNC: 33796
Entrez Gene: 400359
Ensembl: ENSG00000175779
UCSC: uc001zkf.1
No. of Studies 3 (Positive: 0; Negative: 1; trend: 2)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Green, E. K.,2012 SNP: rs12912251 BD ImmunoChip:P-value = 0.029,OR = 1.125;ImmunoChip, PGC-BD combined data:P-balue = 0.000000294,OR = 1.103 Suggestive association was found. Trend Comment on Study
Kranz, T. M.,2012 Haplotype: rs7171233 - rs7165988 - rs2172835(T-C-C), rs7171233 - rs7165988 - rs2172835(A-G-T) Our results indicate that C15orf53 is probably neither causative for the etiology of BD nor for SCZD10 in our samples. Negative Comment on Study
Sklar, P.,2011 SNP: rs12912251 Suggestive association was found. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 0)
Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 12)

Literature-origin SNPs (count: 3)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr15:38696598..38700038 View in gBrowse
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