Gene Report

Basic Info
Approved Symbol DGCR8
Previous Symbol C22orf12
Symbol Alias DGCRK6, Gy1, pasha
Approved Name DGCR8 microprocessor complex subunit
Previous Name chromosome 22 open reading frame 12, "DiGeorge syndrome critical region gene 8"
Location 22q11.2
Position chr22:20080232-20111877, 1
External Links HGNC: 2847
Entrez Gene: 54487
Ensembl: ENSG00000128191
UCSC: uc002zri.3
No. of Studies 2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fallin, M. D.,2005 3 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.12, 1 LD blocks, 0.89 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. Trend Comment on Study
Yosifova, A.,2009 SNP: rs2073778 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 1)

GO terms by database search (count: 17)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 5)

Literature-origin SNPs (count: 1)

LD-proxies (count: 4)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr22:20080232..20111877 View in gBrowse
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