Gene Report

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Basic Info

Approved Symbol	INTS6
Previous Symbol	DDX26
Symbol Alias	DICE1, HDB, Notchl2, DBI-1, DDX26A, INT6
Approved Name	integrator complex subunit 6
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26
Location	13q14.3
Position	chr13:51354077-51454264, -1
External Links	HGNC: 14879 Entrez Gene: 26512 Ensembl: ENSG00000102786 UCSC: uc001vfk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BD:Smallest P-value per gene=0.01196, Product of P truncation <=0.01=0.00611, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007165	signal transduction	biological process	TAS[10467397]	136
GO:0016180	snRNA processing	biological process	IDA[16239144]	2
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005515	protein binding	molecular function	IPI[16239144]	563
GO:0015629	actin cytoskeleton	cellular component	IDA	18
GO:0032039	integrator complex	cellular component	IDA[16239144]	2
GO:0004888	transmembrane signaling receptor activity	molecular function	TAS[10467397]	10

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q12-14	chr13:18900000-54700000	1 (0/1/0)
13q14	chr13:39500000-54700000	3 (0/1/2)
13q13-q14	chr13:31600000-54700000	1 (1/0/0)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	In SZ:Smallest P-value per gene=0.00079, Product of P truncation <=0.01=0.00039, Product of P truncation <=0.001=0.00023 It showed evidence for association with SZ.	Positive

Gene relationship with MDD

View in gBrowse

Region: chr13:51354077..51454264 View in gBrowse