Gene Report

Basic Info
Approved Symbol AGT
Previous Symbol SERPINA8
Approved Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Name Alias alpha-1 antiproteinase, antitrypsin
Location 1q42.2
Position chr1:230702523-230714297, -1
External Links HGNC: 333
Entrez Gene: 183
Ensembl: ENSG00000135744
UCSC: uc001hty.5
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Meira-Lima, I. V.,2000 Other variant: AGT_M235T Our data suggest an association between the AGT M235 genotype and increased susceptibility for BPAD in these Brazilian patients. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 113)

GO terms by PBA (count: 3)

GO terms by database search (count: 110)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 5)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr1:230702523..230714297 View in gBrowse
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