Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	AGT
Previous Symbol	SERPINA8
Approved Name	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Name Alias	alpha-1 antiproteinase, antitrypsin
Location	1q42.2
Position	chr1:230702523-230714297, -1
External Links	HGNC: 333 Entrez Gene: 183 Ensembl: ENSG00000135744 UCSC: uc001hty.5
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Meira-Lima, I. V.,2000	Other variant: AGT_M235T	Our data suggest an association between the AGT M235 genotype and increased susceptibility for BPAD in these Brazilian patients.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 113)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	TAS[3397061]	7
GO:0005179	hormone activity	molecular function	IC[1378723]; ISS	12
GO:0007565	female pregnancy	biological process	IEA	15

GO terms by database search (count: 110)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0050663	cytokine secretion	biological process	IEA	1
GO:1901201	regulation of extracellular matrix assembly	biological process	IGI[17416596]	1
GO:0051403	stress-activated MAPK cascade	biological process	IEA	8
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	biological process	TAS[17159080]	1
GO:0046622	positive regulation of organ growth	biological process	IEA	1
GO:0051969	regulation of transmission of nerve impulse	biological process	IEA	1
GO:0048659	smooth muscle cell proliferation	biological process	IEA	1
GO:0008065	establishment of blood-nerve barrier	biological process	IEA	1
GO:0002018	renin-angiotensin regulation of aldosterone production	biological process	NAS[17159080]	2
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[15153556]	58
GO:0002019	regulation of renal output by angiotensin	biological process	NAS[17159080]	2
GO:0031703	type 2 angiotensin receptor binding	molecular function	IPI[10406457]	1
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0048169	regulation of long-term neuronal synaptic plasticity	biological process	IEA	8
GO:0014061	regulation of norepinephrine secretion	biological process	IEA	1
GO:1900020	positive regulation of protein kinase C activity	biological process	IEA	1
GO:0010535	positive regulation of activation of JAK2 kinase activity	biological process	IMP[15153556]	1
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	TAS[17906677]	12
GO:0002016	regulation of blood volume by renin-angiotensin	biological process	NAS[17159080]	2
GO:0051145	smooth muscle cell differentiation	biological process	IEA	2
GO:0001999	renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	biological process	IEA	1
GO:0016525	negative regulation of angiogenesis	biological process	IEA	5
GO:0072562	blood microparticle	cellular component	IDA[22516433]	8
GO:0007263	nitric oxide mediated signal transduction	biological process	TAS[17159080]	5
GO:0035815	positive regulation of renal sodium excretion	biological process	IEA	5
GO:1903779	regulation of cardiac conduction	biological process	IGI[17416596]	1
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	biological process	IDA[18607644]	3
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	biological process	IDA[15652490]	2
GO:0010744	positive regulation of macrophage derived foam cell differentiation	biological process	IC[18971559]	4
GO:0008285	negative regulation of cell proliferation	biological process	IEA	41
GO:0008217	regulation of blood pressure	biological process	IGI[17416596]	12
GO:0005615	extracellular space	cellular component	IC[1378723]; IDA[16502470]; ISS	85
GO:0033864	positive regulation of NAD(P)H oxidase activity	biological process	TAS[17159080]	2
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	26
GO:0017080	sodium channel regulator activity	molecular function	IMP[15803439]	4
GO:0040018	positive regulation of multicellular organism growth	biological process	IEA	8
GO:0007267	cell-cell signaling	biological process	TAS[8513325]	29
GO:0003051	angiotensin-mediated drinking behavior	biological process	IEA	2
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological process	IEA	10
GO:0016176	superoxide-generating NADPH oxidase activator activity	molecular function	TAS[19193863]	1
GO:0002034	regulation of blood vessel size by renin-angiotensin	biological process	TAS[10406457]	2
GO:0071260	cellular response to mechanical stimulus	biological process	IEA	12
GO:0005576	extracellular region	cellular component	NAS[14718574]; TAS	97
GO:1903598	positive regulation of gap junction assembly	biological process	IGI[17416596]	1
GO:0001974	blood vessel remodeling	biological process	TAS[10406457]	8
GO:0070471	uterine smooth muscle contraction	biological process	IEA	1
GO:0001558	regulation of cell growth	biological process	NAS[17159080]	7
GO:0042127	regulation of cell proliferation	biological process	NAS[17159080]	14
GO:0005515	protein binding	molecular function	IPI[16237761]	563
GO:0044255	cellular lipid metabolic process	biological process	TAS	13
GO:0051924	regulation of calcium ion transport	biological process	IEA	8
GO:0008083	growth factor activity	molecular function	TAS[10406457]	15
GO:0019229	regulation of vasoconstriction	biological process	NAS[17159080]	10
GO:0035813	regulation of renal sodium excretion	biological process	NAS[17159080]	2
GO:0031702	type 1 angiotensin receptor binding	molecular function	IPI[1378723]	3
GO:0014824	artery smooth muscle contraction	biological process	IEA	2
GO:0034374	low-density lipoprotein particle remodeling	biological process	NAS[17069818]	5
GO:1902632	positive regulation of membrane hyperpolarization	biological process	IMP[15803439]	1
GO:0048146	positive regulation of fibroblast proliferation	biological process	ISS	7
GO:0007160	cell-matrix adhesion	biological process	IEA	11
GO:0001568	blood vessel development	biological process	IEA	3
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IEA	13
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	biological process	IDA[10406457]	2
GO:0030432	peristalsis	biological process	IEA	5
GO:0001658	branching involved in ureteric bud morphogenesis	biological process	IEA	6
GO:0010613	positive regulation of cardiac muscle hypertrophy	biological process	ISS	2
GO:0007568	aging	biological process	IEA	22
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	NAS[17159080]	11
GO:0061049	cell growth involved in cardiac muscle cell development	biological process	IEA	1
GO:0014873	response to muscle activity involved in regulation of muscle adaptation	biological process	ISS	1
GO:0032930	positive regulation of superoxide anion generation	biological process	IEA	2
GO:0007202	activation of phospholipase C activity	biological process	IEA	15
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0034104	negative regulation of tissue remodeling	biological process	IEA	1
GO:0042311	vasodilation	biological process	IEA	6
GO:0048143	astrocyte activation	biological process	IEA	2
GO:0010951	negative regulation of endopeptidase activity	biological process	IBA	10
GO:0032270	positive regulation of cellular protein metabolic process	biological process	IDA[18971559]	4
GO:0043410	positive regulation of MAPK cascade	biological process	IEA	13
GO:0001822	kidney development	biological process	IMP[16116425]	13
GO:0050729	positive regulation of inflammatory response	biological process	TAS[17159080]	6
GO:0061098	positive regulation of protein tyrosine kinase activity	biological process	IMP[15153556]	5
GO:0002003	angiotensin maturation	biological process	TAS	3
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IDA[15652490]	9
GO:0006883	cellular sodium ion homeostasis	biological process	IEA	5
GO:0035411	catenin import into nucleus	biological process	IEA	2
GO:0045723	positive regulation of fatty acid biosynthetic process	biological process	IEA	1
GO:0030308	negative regulation of cell growth	biological process	IEA	11
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	biological process	IDA[10406457]	1
GO:0009651	response to salt stress	biological process	IEA	4
GO:0003014	renal system process	biological process	IDA[21183621]	2
GO:0007250	activation of NF-kappaB-inducing kinase activity	biological process	IEA	1
GO:0010595	positive regulation of endothelial cell migration	biological process	IDA[15652490]	4
GO:0070371	ERK1 and ERK2 cascade	biological process	IEA	3
GO:0001543	ovarian follicle rupture	biological process	IEA	2
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IDA[15652490]	12
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[10406457]	64
GO:0010873	positive regulation of cholesterol esterification	biological process	IDA[18971559]	3
GO:2000650	negative regulation of sodium ion transmembrane transporter activity	biological process	TAS[19193863]	2
GO:0003331	positive regulation of extracellular matrix constituent secretion	biological process	IEA	2
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0048144	fibroblast proliferation	biological process	IEA	1
GO:0009409	response to cold	biological process	IEA	7
GO:0001819	positive regulation of cytokine production	biological process	TAS[17906677]	3
GO:0007588	excretion	biological process	IEA	4
GO:0030198	extracellular matrix organization	biological process	IEA	26
GO:2000379	positive regulation of reactive oxygen species metabolic process	biological process	TAS[17906677]	4

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04614	Renin-angiotensin system	4

Gene related BioCarta pathways (count: 5)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 5)

ID	Name	No. of Genes in BDgene
biopeptidesPathway	Bioactive Peptide Induced Signaling Pathway	4
ace2Pathway	Angiotensin-converting enzyme 2 regulates heart function	4
nfatPathway	NFAT and Hypertrophy of the heart (Transcription in the broken heart)	11
At1rPathway	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	4
cardiacegfPathway	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	5

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AGT	CTSG	NO	in vitro	10899625 , 11747312
AGT	AGTR2	NO	in vivo	8185599
AGT	DNPEP	NO	in vivo	12895663
AGT	KNG1	NO	in vivo	11677365
AGT	AGTR1	YES	in vivo	15930094
AGT	MAS1	NO	in vitro	12829792
AGT	ENPEP	NO	in vitro	1756856
AGT	CMA1	YES	in vitro	10899625
AGT	MEP1A	NO	in vitro	11278902
AGT	ACE2	NO	in vitro	10969042 , 11815627
AGT	PRG2	NO	in vitro	7539791
AGT	PRCP	NO	in vitro	28321
AGT	EWSR1	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
AGT_M235T	point mutation		1 (1/0/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q42	chr1:223900000-236400000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
16997000	233	Negative
19086053	233	Negative

Gene relationship with MDD

View in gBrowse

Region: chr1:230702523..230714297 View in gBrowse