Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Comment on Gene

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Basic Info

Approved Symbol	LMO3
Previous Symbol	RBTNL2
Symbol Alias	Rhom-3, DAT1
Approved Name	LIM domain only 3 (rhombotin-like 2)
Location	12p13
Position	chr12:16548373-16610594, -1
External Links	HGNC: 6643 Entrez Gene: 55885 Ensembl: ENSG00000048540 UCSC: uc010shy.2
No. of Studies	3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Keikhaee, M. R.,2005		For the first time, these findings provide tentative evidence of the contribution of the DAT1 gene core promoter polymorphism to the etiopathophysiology of bipolar disorder at least in the Iranian population that we have studied. Interestingly, no allelic or genotype association was observed in the female patients.	Positive	Comment on Study
Georgieva, L.,2002		Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.	Negative	Comment on Study
Greenwood, T. A., 2006	Haplotype: DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078(G-T-G-G-C), DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078(G-G-A-G-C), DAT1_I1+1036 - DAT1_I1+1735 - DAT1_I1+1859 - DAT1_I1+1860 - DAT1_I2+48(), DAT1_I1+1735 - DAT1_I1+1859 - DAT1_I1+1860 - DAT1_I2+48 - DAT1_I5+448(), DAT1_I1+1859 - DAT1_I1+1860 - DAT1_I2+48 - DAT1_I5+448 - DAT1_I6+96(), DAT1_I1+1860 - DAT1_I2+48 - DAT1_I5+448 - DAT1_I6+96 - DAT1_I7+922(), DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217(G-C-G-G-A), DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217(G-C-G-A-A), DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217(A-T-T-A-G), DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274(C-G-G-A-G), DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274(C-G-A-A-C), DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274(T-T-A-G-G), DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274 - DAT1_E15+352(G-G-A-G-G), DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274 - DAT1_E15+352(G-A-A-C-G), DAT1_I12+268 - DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274 - DAT1_E15+352(T-A-G-G-G), DAT1_I13 - 481 - DAT1_I14+4217 - DAT1_E15+274 - DAT1_E15+352 - DAT1_E15VNTR(), DAT1_I14+4217 - DAT1_E15+274 - DAT1_E15+352 - DAT1_E15VNTR - DAT1_E15+1812(A-C-G-9-C), DAT1_I2+48 - DAT1_I5+448 - DAT1_I6+96 - DAT1_I7+922 - DAT1_I8+2086(A-G-G-C-A), DAT1_I5+448 - DAT1_I6+96 - DAT1_I7+922 - DAT1_I8+2086 - DAT1_E9+59(G-G-C-A-G), DAT1_I6+96 - DAT1_I7+922 - DAT1_I8+2086 - DAT1_E9+59 - DAT1_I9+102(G-C-A-G-T), DAT1_I7+922 - DAT1_I8+2086 - DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21(C-A-G-T-G), DAT1_I7+922 - DAT1_I8+2086 - DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21(C-G-G-G-A), DAT1_I8+2086 - DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117(A-G-T-G-G), DAT1_I8+2086 - DAT1_E9+59 - DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117(G-G-G-A-G), DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268(T-G-G-C-G), DAT1_I9+102 - DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268(G-A-G-C-G), DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481(G-G-C-G-G), DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481(A-G-C-G-A), DAT1_I9 - 21 - DAT1_I10+117 - DAT1_I11+2078 - DAT1_I12+268 - DAT1_I13 - 481(G-A-T-T-A), DAT1_P+2459 - DAT1_I1+1036 - DAT1_I1+1735 - DAT1_I1+1859 - DAT1_I1+1860(), DAT1_P215 - DAT1_P+2459 - DAT1_I1+1036 - DAT1_I1+1735 - DAT1_I1+1859()	These data are consistent with the presence of multiple variants in DAT1 that convey susceptibility to bipolar disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

GO terms by PBA (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045600	positive regulation of fat cell differentiation	biological process	IMP[23823477]	9
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	biological process	IDA[23823477]	1
GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	biological process	IDA[23823477]	1
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0005737	cytoplasm	cellular component	IDA[23823477]	322
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0070373	negative regulation of ERK1 and ERK2 cascade	biological process	IDA[23823477]	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 15)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
LMO3	HNRNPM	NO	yeast 2-hybrid	16189514
LMO3	$ZBTB8$	NO	yeast 2-hybrid	16189514
LMO3	ZBTB43	NO	yeast 2-hybrid	16189514
LMO3	GABPB1	NO	yeast 2-hybrid	16189514
LMO3	PHC2	NO	yeast 2-hybrid	16189514
LMO3	LDB1	NO	yeast 2-hybrid	16189514
LMO3	CCDC85B	NO	yeast 2-hybrid	16189514
LMO3	RALYL	NO	yeast 2-hybrid	16189514
LMO3	AIMP2	NO	yeast 2-hybrid	16189514
LMO3	ALS2CR8	NO	yeast 2-hybrid	16189514
LMO3	NHLH2	NO	in vivo	15930276
LMO3	MBIP	NO	yeast 2-hybrid	16189514
LMO3	RFX6	NO	yeast 2-hybrid	16189514
LMO3	C19orf50	NO	yeast 2-hybrid	16189514
LMO3	MDFI	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12p12	chr12:14600000-26300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
11942948	Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr12:16548373..16610594 View in gBrowse