Gene Report

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Basic Info

Approved Symbol	PTGR2
Previous Symbol	ZADH1
Symbol Alias	FLJ39091
Approved Name	prostaglandin reductase 2
Previous Name	zinc binding alcohol dehydrogenase domain containing 1
Location	14q24.1-q24.2
Position	chr14:73851844-73886827, 1
External Links	HGNC: 20149 Entrez Gene: 145482 Ensembl: ENSG00000140043 UCSC: uc001xow.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00377, Product of P truncation <=0.01=0.00079, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008270	zinc ion binding	molecular function	IDA[19000823]	77
GO:0036132	13-prostaglandin reductase activity	molecular function	IEA	1
GO:0047522	15-oxoprostaglandin 13-oxidase activity	molecular function	IDA[19000823]	1
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0006693	prostaglandin metabolic process	biological process	IDA[19000823]	1
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24	chr14:67400000-78800000	1 (0/0/1)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
14q22-24	chr14:50400000-78800000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr14:73851844..73886827 View in gBrowse